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Common antimalarial drugs do not affect the metabolism of diazepam and desmethyldiazepam by human liver microsomes
(University of Nairobi., 1996)
Infection with Plasmodium berghei alters benzodiazepine receptor in rat brain
(University of Nairobi, 1997)
The purpose of this study was to assess the effect of malaria infection on benzodiazepine binding in rat brain. Young male Wistar rats were infected with the rodent parasite Plasmodium berghei, while age-matched control ...
Pharmacokinetics and anticonvulsant effects of diazepam in children with severe falciparum malaria and convulsions
(2002-01)
Convulsions are a common complication of severe malaria in children and are associated with poor outcome. Diazepam is used to terminate convulsions but its pharmacokinetics and pharmacodynamics have not been studied in ...
Effect of malaria infection and endotoxin-induced fever on the metabolism of antipyrine and metronidazole in the rat
(University of Nairobi, 1993-03)
Antipyrine and metronidazole were administered as a cocktail to young (4 weeks old) male Wistar rats (N = 12 for each treatment) to investigate the effect of malaria infection due to the rodent parasite Plasmodium berghei ...
Determination of lorazepam in plasma from children by high-performance liquid chromatography with UV detection
(University of Nairobi, 2005)
A simple, sensitive, selective, and reproducible reversed-phase high-performance liquid chromatographic (HPLC) method with UV detection was developed for the determination of lorazepam (LZP) in human plasma, using oxazepam ...
Pharmacokinetics and clinical efficacy of lorazepam in children with severe malaria and convulsions.
(University of Nairobi, 2008-01)
AIM:
To investigate the pharmacokinetics and clinical efficacy of intravenous (i.v.) and intramuscular (i.m.) lorazepam (LZP) in children with severe malaria and convulsions.
METHODS:
Twenty-six children with severe ...
Pharmacokinetics and clinical effects of phenytoin in children with malaria and convulsions
(University of Nairobi, 2002)
Effect of malaria infection on the pharmacokinetics of paracetamol in rat
(University of Nairobi., 1994-06)
1. Paracetamol (P; 50 and 300 mg/kg i.v.) was administered to the control and malaria-infected (MI) male Wistar rat in order to assess the effect of MI on the metabolism of paracetamol to its glucuronide (PG) and sulphate ...
Metabolism of caffeine and theophylline in rats with malaria and endotoxin-induced fever
(University of Nairobi., 1993-12)
1. The effects of malaria infection due to Plasmodium berghei and Escherichia coli endotoxin-induced fever on the metabolism of orally-administered caffeine (CA: 10 mg/kg) to its primary metabolites (theobromine (TB), ...
Effect of an experimental malaria infection on the metabolism of phenacetin in the rat isolated perfused liver
(University of Nairobi., 1994-08)
1. The effect of infection with the rodent malaria parasite Plasmodium berghei on the metabolism of phenacetin has been investigated in a rat isolated perfused liver preparation. 2. A bolus dose of phenacetin (10 mg) was ...