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Kinetics, distribution, and efficacy of ceftriaxone versus cefazolin in open heart surgery.
(1984)
The effects of cardiopulmonary bypass (CPB) with hypothermia and systemic heparinization on ceftriaxone disposition were evaluated in seven male patients. A bolus dose of drug (14 mg/kg of body weight) was given, and blood ...
Practical therapeutics: treatment of complications of malaria
(1984)
he currently used methods for assessing the therapeutic response to antimalarial drugs are relatively imprecise and insensitive. These methods are inadequate in severe malaria when the objectives of treatment are to save ...
Pharmacokinetics of cyclophosphamide and alkylating activity in man after intravenous and oral administration.
(1979)
Since cyclophosphamide is used by both oral and i.v. routes in the treatment of hematological and solid malignancies, we designed a randomized, crossover clinical trial to evaluate the pharmacokinetics of this anticancer ...
Quaternary isoquinoline alkaloids from Xylopia parviflora.
(2004)
From the quaternary alkaloidal fraction of the bark and the root of Xylopia parviflora (Annonaceae), four isoquinoline alkaloids, xylopinidine, dehydrocoreximine, N, N-dimethylanomurine and N-methylphoebine were isolated ...
Pharmacokinetics of cyclophosphamide in Kenyan African children with lymphoma.
(1984)
The pharmacokinetics of cyclophosphamide have been extensively studied in adult man (Grochow et al., 1979). A few studies have been done to compare the pharmacokinetics of this important anticancer agent in children and ...
Effect of renal insufficiency on the pharmacokinetics of cyclophosphamide and some of its metabolites
(1981)
Cyclophosphamide pharmacokinetics were studied in seven patients with moderate to severe renal insufficiency (creatinine clearances 0-51 ml . min-1), and compared with a matched control group of patients with normal renal ...
The kinetics of salivary elimination of cyclophosphamide in man.
(1979)
The concentrations of cyclophosphamide in plasma and saliva were determined in seven patients following administration of single doses of cyclophosphamide during chemotherapy for lymphoma. 2 The saliva/plasma ratio was ...
Practical therapeutics:some investigations of the toxic effects of the alkaloids extracted from Strychnos henningsii (Gilg) "muteta
(1984)
The effect of alkaloids extracted from strychnos henningsii plant were studied on the normal mice following the intraperitoneal administration on the isolated innerverted skeletal muscles of the rat diaphragm as well as ...
Stimulation of mu and delta opioid receptors induces hyperalgesia while stimulation of kappa receptors induces antinociception in the hot plate test in the naked mole-rat (Heterocephalus glaber).
(University of Nairobi, 2006)
The antinociceptive effects of highly selective mu (DAMGO), delta (DPDPE) and kappa (U-50488 and U-69593) opioid agonists were evaluated following intraperitoneal (i.p.) administration in the naked mole-rat. A hot plate ...