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Subtypes of Human Immunodeficiency Virus Type 1 and Disease Stage among Women in Nairobi, Kenya
(1999)
In sub-Saharan Africa, where the effects of human immunodeficiency virus type 1 (HIV-1) have been most devastating, there are multiple subtypes of this virus. The distribution of different subtypes within African populations ...
The Breadth and Potency of Passively Acquired Human Immunodeficiency Virus Type 1-Specific Neutralizing Antibodies Do Not Correlate with the Risk of Infant Infection[down-pointing small open triangle]
(2011)
Although a major goal of human immunodeficiency virus type 1 (HIV-1) vaccine efforts is to elicit broad and
potent neutralizing antibodies (NAbs), there are no data that directly demonstrate a role for such NAbs in
protection ...
Valacyclovir Suppressive Therapy Reduces Plasma and Breast Milk HIV-1 RNA Levels During Pregnancy and Postpartum: A Randomized Trial
(2012)
Background. The effect of herpes simplex virus type 2 (HSV-2) suppression on human immunodeficiency virus type 1 (HIV-1) RNA in the context of prevention of mother-to-child transmission (PMTCT) interventions is ...
Maternal Human Leukocyte Antigen - A*2301 Is Associated with Increased Mother-to-Child HIV-1 Transmission
(2010)
We examined associations between maternal HLA and vertical HIV-1 transmission in a perinatal cohort of 277 HIV-infected women in Nairobi. HLA class I genes were amplified using sequence-specific oligonucleotide probes and ...
Infant Safety during and after Maternal Valacyclovir Therapy in Conjunction with Antiretroviral HIV-1 Prophylaxis in a Randomized Clinical Trial
(2012)
Background
Maternal administration of the acyclovir prodrug valacyclovir is compatible with pregnancy and breastfeeding. However, the safety profile of prolonged infant and maternal exposure to acyclovir in the context ...
Hormonal contraception and HIV-1 disease progression among postpartum Kenyan women
(2007)
Objective
To assess the immediate and longer-term effects of the use of hormonal contraception on the progression of HIV-1 disease in postpartum women.
Design
A prospective cohort study.
Methods
Information on ...
Highly Active Antiretroviral Therapy (HAART) versus Zidovudine/Nevirapine Effects on Early Breast Milk HIV-1 RNA: A Phase II Randomized Clinical Trial
(2008)
Background
Defining the effect of antiretroviral regimens on breast milk HIV-1 levels is useful to inform the rational design of strategies to decrease perinatal HIV-1 transmission.
Methods
Pregnant HIV-1 seropositive ...
Association of Levels of HIV-1–Infected Breast Milk Cells and Risk of Mother-to-Child Transmission
(2004)
Understanding how the level of human immunodeficiency virus type 1 (HIV-1)–infected breast milk cells (BMCs) affects HIV transmission via breast-feeding can shed light on the mechanism of infection and aid in establishing ...
The Prevalence of Stunting Is High in HIV-1–Exposed Uninfected Infants in Kenya
(2012)
As prevention of mother-to-child HIV-1 transmission (PMTCT) programs decrease the numbers of HIV-1–infected infants, it remains important to improve growth in HIV-1–exposed, uninfected (EU) infants. To determine the growth ...
CCR5, RANTES, and SDF-1 polymorphisms and mother-to-child HIV-1 transmission
(2010)
Among 288 HIV-1-infected, breastfeeding women who received zidovudine prophylaxis and were followed with their infants in Nairobi, we found no associations between maternal genetic polymorphisms in CCR5 (59029G/A, 59353T/C, ...