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Impact of asymptomatic Herpes simplex virus-2 infection on T cell phenotype and function in the foreskin
(University of Nairobi, 2012-06)
Herpes simplex virus type 2 (HSV-2) increases the risk of HIV acquisition in men and overall CD4 T cell density in the foreskin. Using tissues obtained during routine male circumcision, we examined the impact of HSV-2 on ...
HIV infection in uncircumcised men is associated with altered CD8 T cell function but normal CD4 T cell numbers in the foreskin
(2013-11)
Background. HIV-infected (HIV+) men are more susceptible to sexually transmitted infections (STIs), and may also become superinfected by HIV. We hypothesized that HIV induces immune alterations in the foreskin that may ...
No difference in keratin thickness between inner and outer foreskins from elective male circumcisions in Rakai, Uganda.
(University of Nairobi, 2012)
It has been hypothesized that increased HIV acquisition in uncircumcised men may relate to a more thinly keratinized inner foreskin. However, published data are contradictory and potentially confounded by medical indications ...