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The impact of sex work interruption on blood-derived t cells in sex workers from Nairobi, Kenya
(University of Nairobi, 2016)
Background: Unprotected sexual intercourse exposes the female genital tract (FGT) to semen-derived antigens, which leads to a proinflammatory response. Studies have shown that this postcoital inflammatory response can lead ...
PrEP for key populations in combination HIV prevention in Nairobi: a mathematical modelling study
(University of Nairobi, 2017-11)
Background
The HIV epidemic in the population of Nairobi as a whole is in decline, but a concentrated sub-epidemic persists in key populations. We aimed to identify an optimal portfolio of interventions to reduce HIV ...
Periodic presumptive treatment for vaginal infections may reduce the incidence of sexually transmitted bacterial infections.
(University of Nairobi, 2016)
BACKGROUND:
Bacterial vaginosis (BV) may increase women's susceptibility to sexually transmitted infections (STIs). In a randomized trial of periodic presumptive treatment (PPT) to reduce vaginal infections, we observed ...
Repeat use of post-exposure prophylaxis for HIV among Nairobi-based female sex workers following sexual exposure
(Univerisyt of Nairobi, 2015-05)
As ART-based prevention becomes available, effectively targeting these interventions to key populations such as female sex workers (FSW) will be critical. In this study we analyze patterns of repeated post-exposure prophylaxis ...
Regular use of depot medroxyprogesterone acetate causes thinning of the superficial lining and apical distribution of HIV target cells in the human ectocervix
(University of Nairobi, 2020)
Background: The hormonal contraceptive depot medroxyprogesterone acetate (DMPA) may be associated with an increased risk of acquiring human immunodeficiency virus (HIV). We hypothesize that DMPA use influences the ectocervical ...
Medroxyprogesterone Acetate Alters The Vaginal Microbiota And Microenvironment In Women And Increases Susceptibility To Hiv-1 In Humanized Mice
(Medroxyprogesterone Acetate Alters The Vaginal Microbiota And Microenvironment In Women And Increases Susceptibility To Hiv-1 In Humanized Mice, 2019)
The hormonal contraceptive medroxyprogesterone acetate (MPA) is associated with increased risk of human immunodeficiency virus (HIV), via incompletely understood mechanisms. Increased diversity in the vaginal microbiota ...
Prevalence and correlates of common mental health problems and recent suicidal behaviour among female sex workers in Nairobi, Kenya: findings from the Maisha Fiti study
(University of Nairobi, 2021)
Adverse childhood experiences (ACEs), poverty, violence and harmful alcohol/substance are associated with poor mental health outcomes in the general population. These risks are likely to be exacerbated among Female Sex ...
Prevalence, Incidence, and Distribution of Human Papillomavirus Types in Female Sex Workers in Kenya
(UoN, 2020)
Female sex workers (FSWs) have a notably high risk of acquiring human papillomavirus (HPV) infections. Relatively few studies address the type-specific prevalence and incidence of HPV among FSWs in sub-Saharan Africa. FSWs ...