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Naturally occurring protease inhibitor resistance mutations and their frequencies in HIV proviral sequences of drug-naïve sex workers in Nairobi, Kenya
(University of Nairobi, 2014-01-07)
Sub-Saharan Africa accounts for 69% of the people living with HIV globally. An estimated 1,600,000 Kenyans are living with HIV-1. Antiretroviral therapy (ART) has saved 9 million life-years in Sub-Saharan Africa. However, ...
The Expression Analysis of Hexokinase 1 Gene in the Pumwani Commercial Sex Worker Cohort, Nairobi, Kenya
(University of Nairobi, 2014)
Background: Altered susceptibility to HIV-1 infection has been observed in a commercial sex worker (CSW) cohort in Nairobi, Kenya, where a subset of women are classified as HIV-1 exposed yet seronegative (HESN). A gene ...
Prevention of mother-to-child transmission of HIV in Kenya: challenges to implementation
(2014)
Background
The prevention of mother-to-child transmission of human immunodeficiency virus (HIV) is lauded as one of the more successful HIV prevention measures. However, despite some gains in the prevention of mother-to-child ...
Prevention of mother-to-child transmission of HIV in Kenya: challenges to implementation
(University of Nairobi, 2014)
Background:
The prevention of mother-to-child transmission of human immunodeficiency virus (HIV) is lauded as
one of the more successful HIV prevention measures. However, despite some gains in the prevention of ...
Presence of CD8+ T Cells in the Ectocervical Mucosa Correlates with Genital Viral Shedding in HIV-Infected Women despite a Low Prevalence of HIV RNA–Expressing Cells in the Tissue
(2014)
The female genital tract is a portal of entry for sexual HIV transmission and a possible viral reservoir. In this study, the ectocervical CD8+ T cell distribution was explored in situ and was related to expression of CD3 ...
Enrichment of LAG-3, but not PD-1, on Double Negative T Cells at the Female Genital Tract
(University of Nairobi, 2014-12)
Problem
The expression of inhibitory markers such as LAG-3 and PD-1 on T lymphocytes regulates immune function. Their expression at the genital mucosa is poorly understood, but regulation of immune activation at the ...