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Mucosal blood group antigen expression profiles and HIV infections A Study among female sex workers in Kenya.
(University of Nairobi, 2015-07)
Background
The ABO blood group antigens are carbohydrate moieties expressed on human red blood
cells however; these antigens can also be expressed on some other cells particularly the
surface of epithelial cells and may ...
Understanding Adherence to Daily and Intermittent Regimens of Oral HIV Pre-exposure Prophylaxis Among Men Who Have Sex with Men in Kenya.
(2014)
A qualitative assessment of Kenyan men who have sex with men taking daily and intermittent oral HIV pre-exposure prophylaxis (PrEP) found stigma, sex work, mobility, and alcohol impacted adherence. We analyzed quantitative ...
Pregnancy and HIV Disease progression in an early infection cohort from five African countries.
(Unuversity of Nairobi, 2017)
BACKGROUND:
Understanding associations between pregnancy and HIV disease progression is critical to provide appropriate counseling and care to HIV-positive women.
METHODS:
From 2006 to 2011, women less than age 40 ...
Clinical safety and immunogenicity of two hiv vaccines sev-g (np) and ad35-grin in HIV-uninfected, healthy adult volunteers
(University of Nairobi, 2014)
Development of vaccines that stimulate sustained humoral and/or cellular
immunity at mucosal HIV entry points is critical in the quest for an HIV vaccine. To achieve
this goal, we are investigating replication-competent ...
Assessment of anti-hiv-1 antibodies in oral and nasal compartments of volunteers from 3 different populations.
(University of Nairobi, 2016)
In this study, we assessed the feasibility of collecting standardized nasal and salivary samples at centers in Nairobi (Kenya), Kigali (Rwanda), and London (United Kingdom) using different collection devices and media ...
Broad HIV-1 inhibition in vitro by vaccine-elicited cd8(+) t cells in African adults.
(University of Nairobi, 2016)
We are developing a pan-clade HIV-1 T-cell vaccine HIVconsv, which could complement Env vaccines for prophylaxis and be a key to HIV cure. Our strategy focuses vaccine-elicited effector T-cells on functionally and structurally ...
Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort.
(2016)
Broadly neutralizing antibodies (bnAbs) are thought to be a critical component of a protective HIV vaccine. However, designing vaccines immunogens able to elicit bnAbs has proven unsuccessful to date. Understanding the ...
Pregnancy rates among female participants in phase I and phase IIA AIDS vaccine clinical trials in Kenya
(2009-09)
Background: Female participants in AIDS candidate vaccine clinical trials must agree to use effective contraception to be enrolled into the studies, and for a specified period after vaccination, since the candidate vaccines’ ...
Novel Approach For Differential Diagnosis Of Hiv Infections In The Face Of Vaccine-generated Antibodies: Utility For Detection Of Diverse Hiv-1 Subtypes.
(University of Nairobi, 2006)
Because increasing numbers of HIV vaccine candidates are being tested globally, it is essential to differentiate vaccine- from virus-induced antibodies. Most of the currently tested vaccines contain multiple viral components. ...