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Subtype-specific differences in gag-protease-driven replication capacity are consistent with inter-subtype differences in hiv-1 disease progression.
(University of Nairobi, 2017)
There are marked differences in the spread and prevalence of HIV-1 subtypes worldwide, and differences in clinical progression have been reported. However, the biological reasons underlying these differences are unknown. ...
Improving adherence to post-cervical biopsy sexual abstinence in kenyan female sex workers.
(University of Nairobi, 2016)
PROBLEM:
Cervical biopsies offer a unique opportunity for studying local immune response. To investigate hormonally induced immune fluctuations in cervical tissues of Kenyan female sex workers, we improved biopsy sampling ...
HIV-infected women have high numbers of CD103-CD8+ T cells residing close to the basal membrane of the ectocervical epithelium.
(University of Nairobi, 2017)
BACKGROUND:
Genital mucosa is the main portal of entry for various incoming pathogens, including HIV, hence an important site for host immune defenses. Tissue-resident memory T (TRM) cells defend tissue barriers against ...
The incidence of first-line antiretroviral treatment changes and related factors among HIV-infected sex workers in Nairobi, Kenya.
(University of Nairobi, 2017)
INTRODUCTION:
In many settings, several factors including adverse drug reactions and clinical failure can limit treatment choices for combined antiretroviral therapy (cART). The aim of the study was to describe the incidence ...
Genetic markers associated with resistance to beta-lactam and quinolone antimicrobials in non-typhoidal salmonella isolates from humans and animals in central Ethiopia.
(University of Nairobi, 2016)
INTRODUCTION:
Several risk factors including stavudine and age have been strongly associated with polyneuropathy. However, conflicting data exist on height as an independent risk factor in polyneuropathy. The objective ...
Prevalent neuropathy in a cohort of HIV-infected Kenyan sex workers using antiretroviral drugs.
(University of Nairobi, 2016)
INTRODUCTION:
Several risk factors including stavudine and age have been strongly associated with polyneuropathy. However, conflicting data exist on height as an independent risk factor in polyneuropathy. The objective ...
Sexual Assault and HIV Postexposure Prophylaxis at an Urban African Hospital.
(University of Nairobi, 2017)
Antiretroviral postexposure prophylaxis (PEP) may be underutilized in sexual assault cases in Kenya. This study evaluated the characteristics of survivors of sexual violence attending the Gender-Based Violence Recovery ...
The incidence of first-line antiretroviral treatment changes and related factors among HIV-infected sex workers in Nairobi, Kenya.
(University of Nairobi, 2017)
INTRODUCTION:
In many settings, several factors including adverse drug reactions and clinical failure can limit treatment choices for combined antiretroviral therapy (cART). The aim of the study was to describe the incidence ...
Regulation of mucosal and systemic immune activation during the menstrual cycle of female sex workers from nairobi, kenya; local regulation and HIV-induced impairment
(University of Nairobi, 2015)
Problem:
Vaginal intercourse is the main route of HIV infection among women. To result in a productive infection, HIV must encounter activated targets that sustain replication. Sexual hormones modulate activation and ...
Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and an influx of HIV-susceptible target cells.
(University of Nairobi, 2015)
Elevated inflammatory cytokines (EMCs) at mucosal surfaces have been associated with HIV susceptibility, but the underlying mechanisms remain unclear. We characterized the soluble mucosal proteome associated with elevated ...