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Circulating Levels of Tissue Plasminogen Activator and Plasminogen Activator Inhibitor-1 Are Independent Predictors of Coronavirus Disease 2019 Severity: A Prospective, Observational Study
(university of nairobi, 2021)
A substantial pool of evidence suggests that the pathophysiology of the severe form of coronavirus disease 2019 (COVID-19) is mediated, in part, by a hypercoagulable state termed COVID-19-associated coagulopathy (CAC),[1] ...
Simulation-based surgical education for glaucoma versus conventional training alone: the GLAucoma Simulated Surgery (GLASS) trial. A multicentre, multicountry, randomised controlled, investigator-masked educational intervention efficacy trial in Kenya, South Africa, Tanzania, Uganda and Zimbabwe
(university of nairobi, 2021)
Background/aim: Glaucoma accounts for 8% of global blindness and surgery remains an important treatment. We aimed to determine the impact of adding simulation-based surgical education for glaucoma.
Methods: We designed ...
Characteristics and outcomes of patients with an unscheduled return visit within 72 hours to the Paediatric Emergency Centre at a Private Tertiary Referral Hospital in Kenya
(university of nairobi, 2021)
Introduction: Patients' unscheduled return visits (URVs) to the paediatric emergency Centre (PEC) contribute to overcrowding and affect health service delivery and overall quality of care. This study assessed the characteristics ...
Parents' experiences of care and support after stillbirth in rural and urban maternity facilities: a qualitative study in Kenya and Uganda
(university of nairobi, 2021)
Objective: To explore parents' lived experiences of care and support following stillbirth in urban and rural health facilities.
Design: Qualitative, interpretative, guided by Heideggerian phenomenology.
Setting: ...
The Nigral Coup in Parkinson's Disease by α-Synuclein and Its Associated Rebels
(university of nairobi, 2021)
The risk of Parkinson's disease increases with age. However, the etiology of the illness remains obscure. It appears highly likely that the neurodegenerative processes involve an array of elements that influence each other. ...
Detecting Glaucoma in Rural Kenya: Results From a Teleglaucoma Pilot Project in Nyamira, Kenya
(university of nairobi, 2021)
Precis: A teleglaucoma (TG) case-finding model was used in Kenya. Of the patients, 3.46% had definite glaucoma and 4.12% were glaucoma suspects. Most cases were of moderate to advanced stage and referred for further ...
Glycomic-Based Biomarkers for Ovarian Cancer: Advances and Challenges
(university of nairobi, 2021)
Ovarian cancer remains one of the most common causes of death among gynecological malignancies afflicting women worldwide. Among the gynecological cancers, cervical and endometrial cancers confer the greatest burden to the ...
The Emerging Role of Liquid Biopsy in Gastric Cancer
(University of Nairobi, 2021-05)
(1) Background: Liquid biopsy (LB) is a novel diagnostic method with the potential of revolutionizing the prevention, diagnosis, and treatment of several solid tumors. The present paper aims to summarize the current knowledge ...
Annona muricata silver nanoparticles exhibit strong anticancer activities against cervical and prostate adenocarcinomas through regulation of CASP9 and the CXCL1/CXCR2 genes axis
(University of Nairobi, 2021)
Background: Green synthesized nanoparticles have been earmarked for use in nanomedicine including for the development of better anticancer drugs.
Objective: The aim of this study was to undertake biochemical evaluation ...
Rise and fall of total mesorectal excision with lateral pelvic lymphadenectomy for rectal cancer: an updated systematic review and meta-analysis of 11,366 patients
(University of Nairobi, 2021-06)
The role of lateral lymph node dissection (LLND) during total mesorectal excision (TME) for rectal cancer is still controversial. Many reviews were published on prophylactic LLND in rectal cancer surgery, some biased by ...