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Molecular characterization of a tsetse fly midgut proteolytic lectin that mediates differentiation of African trypanosomes.
(2006)
Differentiation of bloodstream-form trypanosomes into procyclic (midgut) forms is an important first step in the establishment of an infection within the tsetse fly. This complex process is mediated by a wide variety of ...
Independent association of hygiene, socioeconomic status, and circumcision with reduced risk of HIV infection among Kenyan men
(University of Washington, 2006)
Among Kenyan men recruited as sex partners of women with genital symptoms, 22 of 150 were HIV seropositive. Because male HIV infection and male hygiene were unexpectedly found to be associated with each other, we examined ...
Stimulation of mu and delta opioid receptors induces hyperalgesia while stimulation of kappa receptors induces antinociception in the hot plate test in the naked mole-rat (Heterocephalus glaber).
(University of Nairobi, 2006)
The antinociceptive effects of highly selective mu (DAMGO), delta (DPDPE) and kappa (U-50488 and U-69593) opioid agonists were evaluated following intraperitoneal (i.p.) administration in the naked mole-rat. A hot plate ...
Correlation between eosinophils and protection against reinfection with Schistosoma mansoni and the effect of human immunodeficiency virus type 1 coinfection in humans.
(University of Nairobi, 2006-04)
Longitudinal investigations of an adult male population of Kenyan car washers who have heavy and quantifiable occupational exposure to Schistosoma mansoni cercariae revealed that some individuals develop resistance to ...
Higher percentages of circulating mast cell precursors correlate with susceptibility to reinfection with Schistosoma mansoni.
(University of Nairobi, 2006-12)
A high level of serum IgE is generally associated with human resistance to schistosomes, though the protective mechanisms of IgE remain undefined. We recently reported that whereas some individuals who are occupationally ...
Studies of a prophylactic HIV-1 vaccine candidate based on modified vaccinia virus Ankara (MVA) with and without DNA priming
(2006)
Background: Two parallel studies evaluated safety and immunogenicity of a prophylactic HIV-1 vaccine in 192 HIV-seronegative, low-risk
volunteers. Modified vaccinia virus Ankara (MVA) and plasmid DNA (pTHr) expressed HIV-1 ...
Steroidal Indoxyls: Evaluation of Pk, values and anti-inflammatory activity
(2006)
Three steroidal indoxyls, 3-oxo-16,17-seco-16;.nor-l,4-androstadien-15-(7'-methoxy-2-indoxyliden)17-oic acid, 1-(2'-indoxyliden)-2-nor-l,2-secocholestan-3~ oic acid and 1-(5'- chloro-2-indoxyliden)-2-nor-l,2-secocholestan-3-oic ...
Prevalence and Antimicrobial susceptibility of staphylococcus aureus at the Kenyatta National Hospital, Nairobi.
(2006)
A cross sectional study of 115 patients admitted at the Department of Orthopedics, Kenyatta National Hospital, Nairobi, Kenya was carried out to determine the prevalence and antibiotic susceptibility of Staphylococcus ...
Generation and characterization of a single-gene mouse-human chimeric antibody against hepatitis B surface antigen
(2006)
BACKGROUND: Antibody against hepatitis B surface antigen (HBsAg) is used for passive immunotherapy in certain cases of hepatitis B infection. The authors have earlier reported a high-affinity mouse monoclonal (5S) against ...
The Genetic Portrait Of An Outbreak Strain
(University of Nairobi, 2006-09)
Unique events in the genome of Mycobacterium tuberculosis, including deletions and IS6110 insertions, have been proposed to be responsible for the virulence phenotype of outbreak strains. Based on this premise, we determined ...