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In vitro activities of 2,4-diaminoquinazoline and 2,4-diaminopteridine derivatives against Plasmodium falciparum
(University of Nairobi, 2004)
The activities of 28 6-substituted 2,4-diaminoquinazolines, 2,4-diamino-5,6,7,8-tetrahydroquinazolines, and 2,4-diaminopteridines against Plasmodium falciparum were tested. The 50% inhibitory concentrations (IC(50)s) of ...
The difference between effectiveness and efficacy of antimalarial drugs in Kenya
(University of Nairobi, 2004)
Objective:To demonstrate the difference between effectiveness and efficacy of antimalarial (AM) drugs in Kenya.
Methods:We undertook a series of linked surveys in four districts of Kenya between 2001 and 2002 on (i) ...
WHO, the Global Fund, and medical malpractice in malaria treatment
(University of Nairobi, 2004)
A randomised, controlled trial of once daily and multi-dose daily gentamicin in young Kenyan infants
(University of Nairobi, 2004-07)
AIMS: To test the suitability of a simple once daily (OD) gentamicin regimen for use in young infants where routine therapeutic drug monitoring is not possible. METHODS: In an open, randomised, controlled trial, infants ...
Therapeutic potential of folate uptake inhibition in Plasmodium falciparum
(University of Nairobi, 2004)
Plasmodium falciparum parasites resistant to the combination sulfadoxine-pyrimethamine are spreading in Africa, particularly in East Africa. This is a matter of concern because there are no other affordable drugs available. ...
Determination of paraldehyde by gas chromatography in whole blood from children
(University of Nairobi, 2004-06)
A rapid, sensitive and selective gas chromatographic method with flame ionization detection was developed for the determination of paraldehyde in small blood samples taken from children. Whole blood samples (300 microl) ...