T cell anergy and activation are associated with suboptimal humoral responses to measles revaccination in HIV-infected children on antiretroviral therapy in Nairobi, Kenya
Newman, Laura P.
Chohan, Bhavna H.
Buechler, Matthew B.
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HIV-infected children are less capable of mounting and maintaining protective humoral responses to vaccination against measles compared to HIV-uninfected children. This poses a public health challenge in countries with high HIV burdens. Administration of antiretroviral therapy (ART) and revaccinating children against measles is one approach to increase measles immunity in HIV-infected children, yet it is not effective in all cases. Immune anergy and activation during HIV infection are factors that could influence responses to measles revaccination. We utilized a flow cytometry-based approach to examine whether T cell anergy and activation were associated with the maintenance of measles-specific IgG antibodies generated in response to measles revaccination in a cohort of HIV-infected children on ART in Nairobi, Kenya. Children who sustained measles-specific IgG for at least one year after revaccination displayed significantly lower Programmed Cell Death 1 (PD1) surface expression on CD8+ T cells on a per-cell basis and exhibited less activated CD4+ T cells compared to those unable to maintain detectable measles-specific antibodies. Children in both groups were similar in age and sex, CD4+ T cell frequency, duration of ART treatment and HIV viral load at enrollment. These data suggest that aberrant T cell anergy and activation are associated with the impaired ability to sustain an antibody response to measles revaccination in HIV-infected children on ART.
CitationBuechler, Matthew B., et al. "T cell anergy and activation are associated with suboptimal humoral responses to measles revaccination in HIV‐infected children on antiretroviral therapy in Nairobi, Kenya." Clinical & Experimental Immunology (2015).
University of Nairobi