dc.contributor.author | Newman, Laura P. | |
dc.contributor.author | Chohan, Bhavna H. | |
dc.contributor.author | Njoroge, Anne | |
dc.contributor.author | Wamalwa, Dalton | |
dc.contributor.author | Carey, Farquhar | |
dc.contributor.author | Buechler, Matthew B. | |
dc.date.accessioned | 2015-04-24T07:35:40Z | |
dc.date.available | 2015-04-24T07:35:40Z | |
dc.date.issued | 2015 | |
dc.identifier.citation | Buechler, Matthew B., et al. "T cell anergy and activation are associated with suboptimal humoral responses to measles revaccination in HIV‐infected children on antiretroviral therapy in Nairobi, Kenya." Clinical & Experimental Immunology (2015). | en_US |
dc.identifier.uri | http://onlinelibrary.wiley.com/doi/10.1111/cei.12619/abstract | |
dc.identifier.uri | http://hdl.handle.net/11295/82020 | |
dc.description.abstract | HIV-infected children are less capable of mounting and maintaining protective humoral responses to vaccination against measles compared to HIV-uninfected children. This poses a public health challenge in countries with high HIV burdens. Administration of antiretroviral therapy (ART) and revaccinating children against measles is one approach to increase measles immunity in HIV-infected children, yet it is not effective in all cases. Immune anergy and activation during HIV infection are factors that could influence responses to measles revaccination. We utilized a flow cytometry-based approach to examine whether T cell anergy and activation were associated with the maintenance of measles-specific IgG antibodies generated in response to measles revaccination in a cohort of HIV-infected children on ART in Nairobi, Kenya. Children who sustained measles-specific IgG for at least one year after revaccination displayed significantly lower Programmed Cell Death 1 (PD1) surface expression on CD8+ T cells on a per-cell basis and exhibited less activated CD4+ T cells compared to those unable to maintain detectable measles-specific antibodies. Children in both groups were similar in age and sex, CD4+ T cell frequency, duration of ART treatment and HIV viral load at enrollment. These data suggest that aberrant T cell anergy and activation are associated with the impaired ability to sustain an antibody response to measles revaccination in HIV-infected children on ART. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.subject | T cells; revaccination; measles; HIV; ART | en_US |
dc.title | T cell anergy and activation are associated with suboptimal humoral responses to measles revaccination in HIV-infected children on antiretroviral therapy in Nairobi, Kenya | en_US |
dc.type | Article | en_US |
dc.type.material | en | en_US |