dc.contributor.author | McKinnon, Lyle R | |
dc.contributor.author | Ball, T Blake | |
dc.contributor.author | Wachihi, Charles | |
dc.contributor.author | McLaren, Paul J | |
dc.contributor.author | Waruk, Jillian LM | |
dc.contributor.author | Mao, Xiaojuan | |
dc.contributor.author | Ramdahin, Sue | |
dc.contributor.author | Anzala, A Omu | |
dc.contributor.author | Kamene, Jane | |
dc.contributor.author | Luo, Ma | |
dc.contributor.author | Fowke, Keith R | |
dc.contributor.author | Plummer, Francis A | |
dc.date.accessioned | 2015-05-19T07:52:47Z | |
dc.date.available | 2015-05-19T07:52:47Z | |
dc.date.issued | 2007-03 | |
dc.identifier.citation | The Journal of Immunology March 15, 2007 vol. 178 no. 6 3750-3756 | en_US |
dc.identifier.uri | http://www.jimmunol.org/content/178/6/3750.short | |
dc.identifier.uri | http://hdl.handle.net/11295/83146 | |
dc.description.abstract | HIV diversity may limit the breadth of vaccine coverage due to epitope sequence differences between strains. Although amino acid substitutions within CD8+ T cell HIV epitopes can result in complete or partial abrogation of responses, this has primarily been demonstrated in effector CD8+ T cells. In an HIV-infected Kenyan cohort, we demonstrate that the cross-reactivity of HIV epitope variants differs dramatically between overnight IFN-γ and longer-term proliferation assays. For most epitopes, particular variants (not the index peptide) were preferred in proliferation in the absence of corresponding overnight IFN-γ responses and in the absence of the variant in the HIV quasispecies. Most proliferating CD8+ T cells were polyfunctional via cytokine analyses. A trend to positive correlation was observed between proliferation (but not IFN-γ) and CD4 counts. We present findings relevant to the assessment of HIV vaccine candidates and toward a better understanding of how viral diversity is tolerated by central and effector memory CD8+ T cells. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Univerisyt of Nairobi | en_US |
dc.title | Epitope cross-reactivity frequently differs between central and effector memory HIV-specific CD8+ t cells1 | en_US |
dc.type | Article | en_US |
dc.type.material | en | en_US |