HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 Loads
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Date
2007Author
Baeten, Jared M.
Chohan, Bhavna
Lavreys, Ludo
Chohan, Vrasha
McClelland, R. Scott
Certain, Laura
Mandaliya, Kishorchandra
Jaoko Walter G.
Overbaugh, Julie
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
We investigated the effect of human immunodeficiency virus
type 1 (HIV-1) subtype on disease progression among 145
Kenyan women followed from the time of HIV-1 acquisition.
Compared with those infected with subtype A, women infected
with subtype D had higher mortality (hazard ratio,
2.3 [95% confidence interval, 1.0–5.6]) and a faster rate of
CD4 cell count decline (Pp.003). The mortality risk persisted
after adjustment for plasma HIV-1 load. There were
no differences in plasma viral load by HIV-1 subtype during
follow-up. HIV-1 subtype D infection is associated with a
12-fold higher risk of death than subtype A infection, in
spite of similar plasma HIV-1 loads.
URI
http://www.ncbi.nlm.nih.gov/pubmed/17357054http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/9869
Citation
JID 2007:195Collections
- Faculty of Health Sciences (FHS) [10387]