HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 Loads

dc.contributor.author	Baeten, Jared M.
dc.contributor.author	Chohan, Bhavna
dc.contributor.author	Lavreys, Ludo
dc.contributor.author	Chohan, Vrasha
dc.contributor.author	McClelland, R. Scott
dc.contributor.author	Certain, Laura
dc.contributor.author	Mandaliya, Kishorchandra
dc.contributor.author	Jaoko Walter G.
dc.contributor.author	Overbaugh, Julie
dc.date.accessioned	2013-02-14T10:59:15Z
dc.date.available	2013-02-14T10:59:15Z
dc.date.issued	2007
dc.identifier.citation	JID 2007:195	en
dc.identifier.uri	http://www.ncbi.nlm.nih.gov/pubmed/17357054
dc.identifier.uri	http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/9869
dc.description.abstract	We investigated the effect of human immunodeficiency virus type 1 (HIV-1) subtype on disease progression among 145 Kenyan women followed from the time of HIV-1 acquisition. Compared with those infected with subtype A, women infected with subtype D had higher mortality (hazard ratio, 2.3 [95% confidence interval, 1.0–5.6]) and a faster rate of CD4 cell count decline (Pp.003). The mortality risk persisted after adjustment for plasma HIV-1 load. There were no differences in plasma viral load by HIV-1 subtype during follow-up. HIV-1 subtype D infection is associated with a 12-fold higher risk of death than subtype A infection, in spite of similar plasma HIV-1 loads.	en
dc.language.iso	en	en
dc.title	HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 Loads	en
dc.type	Article	en