dc.contributor.author | McKinnon, Lyle R. | |
dc.contributor.author | Ball, T. Blake | |
dc.contributor.author | Wachihi, Charles | |
dc.contributor.author | McLaren, Paul J. | |
dc.contributor.author | Waruk, Jillian L. M. | |
dc.contributor.author | Mao, Xiaojuan | |
dc.contributor.author | Ramdahin, Sue | |
dc.contributor.author | Anzala, A. Omu | |
dc.contributor.author | Kamene, Jane | |
dc.contributor.author | Luo, Ma | |
dc.contributor.author | Fowke, Keith R. | |
dc.contributor.author | Plummer, Francis A. | |
dc.date.accessioned | 2013-02-14T14:59:10Z | |
dc.date.available | 2013-02-14T14:59:10Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | The Journal of Immunology, 2007, 178: 3750–3756. | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/9923 | |
dc.description.abstract | HIV diversity may limit the breadth of vaccine coverage due to epitope sequence differences between strains. Although amino acid
substitutions within CD8 T cell HIV epitopes can result in complete or partial abrogation of responses, this has primarily been
demonstrated in effector CD8 T cells. In an HIV-infected Kenyan cohort, we demonstrate that the cross-reactivity of HIV epitope
variants differs dramatically between overnight IFN- and longer-term proliferation assays. For most epitopes, particular variants
(not the index peptide) were preferred in proliferation in the absence of corresponding overnight IFN- responses and in the
absence of the variant in the HIV quasispecies. Most proliferating CD8 T cells were polyfunctional via cytokine analyses. A trend
to positive correlation was observed between proliferation (but not IFN- ) and CD4 counts. We present findings relevant to the
assessment of HIV vaccine candidates and toward a better understanding of how viral diversity is tolerated by central and effector
memory CD8 T cells. | en |
dc.language.iso | en | en |
dc.subject | Immunology | en |
dc.subject | HIV-Specific | en |
dc.subject | CD8+ T Cells | en |
dc.title | Epitope Cross-Reactivity Frequently Differs between Central and Effector Memory HIV-Specific CD8 T Cells1 | en |
dc.type | Article | en |