Factors associated with virological failure among patients on second-line ART at Kenyatta national hospital.
Abstract
Background: The HIV/AIDS scourge posture a serious difficulty to authorities, health operations,
including societies throughout the globe. Relevant utilization regarding antiretroviral (ARV’s) has
enhanced the well-being of several humans with the immunodeficiency virus (HIV). Significant
effectiveness regarding HIV medication depends upon the sustenance of immense levels
concerning adherence to ARV; notwithstanding, ARV regimens remain often times intricate
moreover it can be altered on changing dosing schedules, failing to have decent dietary
specifications including subjects exhibiting adverse outcomes. More than half of people in low
and middle income nations may not sustain viral suppression on second-line antiretroviral therapy
(ART), according to research proffered at the 25th Conference on Retroviruses and Opportunistic
Infections (CROI 2018). Entrance toward second-line antiretroviral medication (ART) concerning
HIV-positive subjects continues inadequately within South of the Sahara. The World Health
Organization advocates a second-line ART for grown-ups of a pair of nucleoside reversetranscriptase inhibitors + a ritonavir-boosted protease inhibitor. Viral load is recommended on a
specific plan of medication as the favored observation procedure for diagnosis and verification of
ARV regimen breakdown furthermore if viral load is regularly unavailable
Study Objective: To use multivariate analysis techniques to establish clinical and socio
demographic factors related to second-line ART virological failure for patients on follow-up at
KNH-CCC.
Methodology: Exploratory analysis was conducted on the categorical variables to provide
summaries of the data. Further inferential analysis was done using multivariate and cluster
analysis. A multivariable analysis was applied to concurrently examine whether multiple risk
factors (referred to as independent variables) are associated with a specific outcome (attributed to
as the dependent variable).
Justification: It is important that the patients on second line ART treatment continue staying
on this treatment. This study provides important baseline information of factors associated with
failure of second line ART which can be addressed and investigated further to avoid patients being
changed to third line ART treatment with its complications and cost implications.
Publisher
University of Nairobi
Rights
Attribution-NonCommercial-NoDerivs 3.0 United StatesUsage Rights
http://creativecommons.org/licenses/by-nc-nd/3.0/us/Collections
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