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Elevated expression of LAG-3, but not PD-1, is associated with impaired iNKT cytokine production during chronic HIV-1 infection and treatment
(University of Nairobi, 2015)
Background:
LAG-3 is a potent negative regulator of the immune response but its impact in HIV infection in
poorly understood. Unlike exhaustion markers such as PD-1, Tim-3, 2B4 and CD160, LAG-3 is poorly expressed on
bulk ...
Enrichment of LAG-3, but not PD-1, on Double Negative T Cells at the Female Genital Tract
(University of Nairobi, 2014-12)
Problem
The expression of inhibitory markers such as LAG-3 and PD-1 on T lymphocytes regulates immune function. Their expression at the genital mucosa is poorly understood, but regulation of immune activation at the ...
The impact of sex work interruption on blood-derived t cells in sex workers from Nairobi, Kenya
(University of Nairobi, 2016)
Background: Unprotected sexual intercourse exposes the female genital tract (FGT) to semen-derived antigens, which leads to a proinflammatory response. Studies have shown that this postcoital inflammatory response can lead ...
PrEP for key populations in combination HIV prevention in Nairobi: a mathematical modelling study
(University of Nairobi, 2017-11)
Background
The HIV epidemic in the population of Nairobi as a whole is in decline, but a concentrated sub-epidemic persists in key populations. We aimed to identify an optimal portfolio of interventions to reduce HIV ...
Periodic presumptive treatment for vaginal infections may reduce the incidence of sexually transmitted bacterial infections.
(University of Nairobi, 2016)
BACKGROUND:
Bacterial vaginosis (BV) may increase women's susceptibility to sexually transmitted infections (STIs). In a randomized trial of periodic presumptive treatment (PPT) to reduce vaginal infections, we observed ...
Multiplex detection of bacteria associated with normal microbiota and with bacterial vaginosis in vaginal swabs by use of oligonucleotide-coupled fluorescent microspheres
(2009)
Bacterial vaginosis (BV) is a recurrent condition that is associated with a range of negative outcomes,
including the acquisition of human immunodeficiency virus and other sexually transmitted diseases,
preterm births, ...
HIV-1 Clade D Is Associated with Increased Rates of CD4 Decline in a Kenyan Cohort
(2012)
HIV-1 is grouped phylogenetically into clades, which may impact rates of HIV-1 disease progression. Clade D infection in
particular has been shown to be more pathogenic. Here we confirm in a Nairobi-based prospective ...
Cervical HIV-specific IgA in a population of commercial sex workers correlates with repeated exposure but not resistance to HIV
(2009)
We conducted a comprehensive cross-sectional analysis of total and HIV-specific cervical antibody levels in HIV-
1-resistant, uninfected, and infected women in order to examine the role of HIV-specific antibody responses ...