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Antimicrobial and antiparasitic abietane diterpenoids from the roots of Clerodendrum eriophyllum
(University of Nairobi, 2010-06)
Chromatographic separation of the roots of a Kenyan medicinal plant, Clerodendrum eriophyllum, led to the isolation of ten abietane diterpenoids (1-10), one of which (1) was isolated for the first time from a natural source. ...
Anti-plasmodial Activities Of Flavonoids From Erythrina Sacleuxii
(University of Nairobi, 2006-02)
The acetone extracts of the root bark and stem bark of Erythrina sacleuxii showed antiplasmodial activities against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum. Chromatographic ...
Flavonoids and Isoflavonoids with Antiplasmodial Activities from the Root Bark of Erythrina abyssinica
(University of Nairobi, 2003-07)
From the root bark of Erythrina abyssinica a new pterocarpene [3-hydroxy-9-methoxy-10-(3,3-dimethylallyl)pterocarpene] and a new isoflav-3-ene [7,4′-dihydroxy-2′,5′-dimethoxyisoflav-3-ene] were isolated. In addition, the ...
Antiparasitic and anticancer carvotacetone derivatives from Sphaeranthus bullatus
(2012-09)
The 1:1 MeOH/CH2Cl2 extract of aerial parts of Sphaeranthus bullatus, an annual herb native to tropical East Africa, showed activity against chloroquine sensitive D6 (IC50 9.7µg/ml) and chloroquine resistant W2 (IC50 ...
Three isoflav-3-enes and a 2-arylbenzofuran from the root bark of Erythrina burttii
(University of Nairobi, 2002-02)
From the root bark of Erythrina burttii three isoflav-3-enes, 7,4′-dihydroxy-2′-methoxy-6-(1″,1″-dimethylallyl)isoflav-3-ene (trivial name, burttinol-A), 4′-hydroxy-2′-methoxy-2″,2″-dimethylpyrano[5″,6″:8,7]isoflav-3-ene ...
Effect of rotenoids from the seeds of Millettia dura on larvae of Aedes aegypti
(University of Nairobi, 2003-10)
A crude chloroform extract of seeds of Millettia dura Dunn (Leguminosae) showed high activity (LC50 = 3.5 µg ml−1 at 24 h) against second-instar larvae of the mosquito, Aedes aegypti L (Diptera: Culicidae). The rotenoids, ...
Antimicrobial flavonoids from the stem bark of Erythrina burttii
(University of Nairobi, 2005-07)
The chloroform extract of the stem bark of Erythrina burttii showed antifungal and antibacterial activities using the disk diffusion method. Flavonoids were identified as the active principles. Activities were observed ...
Investigation of some medicinal plants traditionally used for treatment of malaria in Kenya as potential sources of antimalarial drugs.
(University of Nairobi, 2011-03)
Malaria is a major public health problem in many tropical and subtropical countries and the burden of this disease is getting worse, mainly due to the increasing resistance of Plasmodium falciparum against the widely ...
C-methylated and C-prenylated isoflavonoids from root extract of Desmodium uncinatum
(University of Nairobi, 2007-03-05)
A pterocarpan, 1,9-dihydroxy-3-methoxy-2-methylpterocarpan (named uncinacarpan) and two isoflavanones, 5,7-dihydroxy-2′,3′,4′-trimethoxy-6-(3-methylbut-2-enyl)isoflavanone (named uncinanone D) and 5,4′-dihydroxy-7,2′-dim ...
Preliminary studies on antipyretic and analgesic properties of Taverniera abyssinica
(University of Nairobi, 1990-10)
In an attempt to ascertain the pharmacological basis of the use of the marketed traditional drug Taverniera abyssinica A. Rich. (Amharic name Dingetegna), crude extracts as well as purified substances of this plant were ...