Faculty of Science & Technology (FST): Recent submissions

Now showing items 1461-1480 of 4283

    • Comparison of two microdiffusion methods used to measure ionizable fluoride in cows' milk. 

      Kimarua, RW; Kariuki, David N; Njenga, LW (University of NairobiDepartment of Chemistry, 1995-08)
      Two microdiffusion methods for measuring ionizable fluoride in cows' milk have been compared. The comparison includes diffusion time, amount of fluoride in spiked and unspiked milk samples and the effect of aluminium as ...

    • Inhibition of c-Kit, VEGFR-2 (KDR), and ABCG2 by analogues of OSI-930 

      Patel, JP; Kuang, YH; Chen, ZS; Korlipara, VL (College of Biological and Physical Sciences ,Department of physics, 2011)
      The quinoline domain of OSI-930, a dual inhibitor of receptor tyrosine kinases (RTKs) c-Kit and KDR, was modified in an effort to further understand the SAR of OSI-930, and the binding site characteristics of c-Kit and ...

    • Effect of interfering ions on hexamethyldisiloxane microdiffusion method 

      Kahama, RW; Kariuki, DN; Njenga, LW (University of NairobiDepartment of Chemistry, 1997-10)
      Acid diffusion in the presence of hexamethyldisiloxane (HMDS) enables complete recovery of ionic fluoride from standards containing varying concentrations of aluminium as one of the main interfering ions. Acid diffusion ...

    • Prognostic relevance of integrated genetic profiling in acute myeloid leukemia 

      Huberman, K; Aminova, O; Thomas, S; Dolgalev, L; Van Vlierberghe, P; Racevskis, J; Sun, Z; Fernandez, H; Figueroa, ME; Gönen, M; Patel, JP; Cheng, J; van den Brink, MR; Litzow, M; Gallagher, RE; Ketterling, RP; Viale, A; Socci, ND; Heguy, A; Cherry, A; Vance, G; Higgins, RR; Levine, RL; Abdel-Wahab, O; Melnick, A; Tallman, MS; Paietta, E; Ferrando, A; Luger, S; Rowe, JM; Lazarus, HM (College of Biological and Physical Sciences ,Department of physics, 2012)
      BACKGROUND: Acute myeloid leukemia (AML) is a heterogeneous disease with respect to presentation and clinical outcome. The prognostic value of recently identified somatic mutations has not been systematically evaluated ...

    • Effect of serum lipoproteins on stereoselective halofantrine metabolism by rat hepatocytes 

      Patel, JP; Hamdy, DA; El-Kadi, AO; Brocks, DR (College of Biological and Physical Sciences ,Department of physics, 2012)
      Experimental hyperlipidemia has shown to decrease cytochrome P450 3A4 and 2C11 expression and to increase liver concentrations and the plasma protein binding of halofantrine (HF) enantiomers. The present study examined the ...

    • OSI-930 analogues as novel reversal agents for ABCG2-mediated multidrug resistance 

      Kuang, YH; Patel, JP; Sodani, K; Wu, CP; Liao, LQ; Patel, A; Tiwari, AK; Dai, CL; Chen, X; Fu, LW; Ambudkar, SV; Korlipara, VL; Chen, ZS (College of Biological and Physical Sciences ,Department of physics, 2012)
      OSI-930, a dual c-Kit and KDR tyrosine kinase inhibitor, is reported to have undergone a Phase I dose escalation study in patients with advanced solid tumors. A series of fifteen pyridyl and phenyl analogues of OSI-930 ...

    • CD25 expression status improves prognostic risk classification in AML independent of established biomarkers: ECOG phase 3 trial, E1900 

      Gönen, M; Sun, Z; Figueroa, ME; Patel, JP; Abdel-Wahab, O; Racevskis, J; Ketterling, RP; Fernandez, H; Rowe, JM; Tallman, MS; Melnick, A; Levine, RL; Paietta, E (College of Biological and Physical Sciences ,Department of physics, 2012)
      We determined the prognostic relevance of CD25 (IL-2 receptor-α) expression in 657 patients (≤ 60 years) with de novo acute myeloid leukemia (AML) treated in the Eastern Cooperative Oncology Group trial, E1900. We identified ...

    • ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression 

      Levine, RL; Bernstein, BE; Aifantis, I; Jaffe, JD; Nimer, SD; Melnick, A; Carroll, M; Abdel-Wahab, O; Park, CY; Taylor, JE; Zhao, X; Perna, F; Koche, R; Chung, YR; Patel, JP; Pandey, S; Shih, AH; Hricik, T; Gao, J; LaFave, LM; Adli, M (College of Biological and Physical Sciences ,Department of physics, 2012)
      Recurrent somatic ASXL1 mutations occur in patients with myelodysplastic syndrome, myeloproliferative neoplasms, and acute myeloid leukemia, and are associated with adverse outcome. Despite the genetic and clinical data ...

    • Effect of rat serum lipoproteins on mRNA levels and amiodarone metabolism by cultured primary rat hepatocytes 

      Brocks, DR; Hamdy, DA; Ben-Eltriki, M; Patel, JP; El-Kadi, AO (College of Biological and Physical Sciences ,Department of physics, 2013)
      Hyperlipidemia can significantly increase amiodarone (AM) in vivo liver uptake and decrease its velocity of microsomal metabolism. Here, hepatocytes isolated from normolipidemic (NL) and hyperlipidemic rats were incubated ...

    • How do novel molecular genetic markers influence treatment decisions in acute myeloid leukemia? 

      Patel, JP; Levine, RL (College of Biological and Physical Sciences ,Department of physics, 2012)
      Acute myeloid leukemia (AML) is the most common acute leukemia diagnosed in adults, and the majority of patients with AML die from relapsed disease. Although many studies over the past 4 decades have identified disease ...

    • Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia 

      Meyer, JA; Wang, J; Hogan, LE; Yang, JJ; Dandekar, S; Patel, JP; Tang, Z; Zumbo, P; Li, S; Zavadil, J; Levine, RL; Cardozo, T; Hunger, SP; Raetz, EA; Evans, WE; Morrison, DJ; Mason, CE; Carroll, WL (College of Biological and Physical Sciences ,Department of physics, 2013)
      Relapsed childhood acute lymphoblastic leukemia (ALL) carries a poor prognosis, despite intensive retreatment, owing to intrinsic drug resistance. The biological pathways that mediate resistance are unknown. Here, we report ...

    • Serum 2-hydroxyglutarate levels predict isocitrate dehydrogenase mutations and clinical outcome in acute myeloid leukemia 

      DiNardo, CD; Propert, KJ; Loren, AW; Paietta, E; Sun, Z; Levine, RL; Straley, KS; Yen, K; Patel, JP; Agresta, S; Abdel-Wahab, O; Perl, AE; Litzow, MR; Rowe, JM; Lazarus, HM; Fernandez, HF; Margolis, DJ; Tallman, MS; Luger, SM; Carroll, M (College of Biological and Physical Sciences ,Department of physics, 2013)
      Cancer-associated isocitrate dehydrogenase (IDH) mutations produce the metabolite 2-hydroxyglutarate (2HG), but the clinical utility of 2HG has not been established. We studied whether 2HG measurements in acute myeloid ...

    • Hydrologic Analysis For River Nyando Using SWAT 

      Opere Alfred O. (University of NairobiDepartment of Meteorology, 2011)
      The Nyando River is one of the major Rivers in the Lake Victoria Basin. It drains parts of Nandi, Kericho and Nyando districts. It has a catchment area of about 3600km−2 of Western Kenya and an average discharge of ...

    • More on normal prothrombin times in the presence of therapeutic levels of rivaroxaban - early experience from King's College Hospital 

      Patel, JP; Roberts, LN; Chitongo, PB; Patel, RK; Arya, R (College of Biological and Physical Sciences ,Department of physics, 2013)

    • Point mutation E1099K in MMSET/NSD2 enhances its methyltranferase activity and leads to altered global chromatin methylation in lymphoid malignancies 

      Oyer, JA; Huang, X; Zheng, Y; Shim, J; Ezponda, T; Carpenter, Z; Allegretta, M; Okot-Kotber, CI; Patel, JP; Melnick, A; Levine, RL; Mackerell, AD; Kelleher, NL; Licht, JD; Popovic, R (College of Biological and Physical Sciences ,Department of physics, 2013)

    • The role of mutations in epigenetic regulators in myeloid malignancies 

      Shih, AH; Abdel-Wahab, O; Patel, JP; Levine, RL (College of Biological and Physical Sciences ,Department of physics, 2012)
      The role of mutations in epigenetic regulators in myeloid malignancies. Recent genomic studies have identified novel recurrent somatic mutations in patients with myeloid malignancies, including myeloproliferative ...

    • Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis 

      Levine, RL; Abdel-Wahab, O; Brennan, CW; Godley, LA; Melnick, A; Mason, CE; Gonen, M; Bhatt, PK; Socci, N; Hassimi, M; Heguy, A; Viale, A; Li, J; Mollica, L; Hamilou, Z; Provost, S; Vasanthakumar, A; Busque, L; Patel, JP; Figueroa, ME (College of Biological and Physical Sciences ,Department of physics, 2012)
      Abstract Aging is characterized by clonal expansion of myeloid-biased hematopoietic stem cells and by increased risk of myeloid malignancies. Exome sequencing of three elderly females with clonal hematopoiesis, demonstrated ...

    • Acute myeloid leukemia with translocation t(8;16) presents with features which mimic acute promyelocytic leukemia and is associated with poor prognosis 

      Diab, A; Zickl, L; Abdel-Wahab, O; Jhanwar, S; Gulam, MA; Panageas, KS; Patel, JP; Jurcic, J; Maslak, P; Paietta, E; Mangan, JK; Carroll, M; Fernandez, HF; Teruya-Feldstein, J; Luger, SM; Douer, D; Litzow, MR,; Lazarus, HM; Rowe, JM; Levine, RL; Tallman, MS (College of Biological and Physical Sciences ,Department of physics, 2013)
      Previous small series have suggested that acute myeloid leukemia with t(8;16) is a distinct morphologic and clinical entity associated with poor prognosis. We describe 18 patients with t(8;16) AML, including their clinical, ...

    • Cytotoxic lupane-type triterpenoids from Acacia mellifera. 

      Mutai, C; Abatis, D; Vagias, C; Moreau, D; Roussakis, C; Roussis, V (2004)
      One new and eight previously described lupane-type metabolites were isolated for the first time from Acacia mellifera (Leguminosae). Based on spectral analyses, the structure of the new compound was elucidated as ...

    • In vivo screening of antimalarial activity of Acacia mellifera (Benth) (Leguminosae) on Plasmodium berghei in mice. 

      Mutai, C; Rukunga, G; Vagias, C; Roussis, V (2007)
      The activities of total extracts and lupane triterpenes, isolated from the stem bark of Acacia mellifera, were evaluated against Plasmodium berghei strain ANKA in a female Swiss mouse model. Five isolated compounds and the ...