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Biological Factors That May Contribute To Regional And Racial Disparities In Hiv Prevalence
(University of Nairobi, 2011-03)
Despite tremendous regional and subregional disparities in HIV prevalence around the world, epidemiology consistently demonstrates that black communities have been disproportionately affected by the pandemic. There are ...
HIV-1 viral control varies by viral subtype in a large cohort of African adults with incident HIV-1 infection.
(Oxford Academic, 2019-04-02)
Few HIV-infected persons can maintain low viral levels without therapeutic intervention. We evaluate predictors of spontaneous viral control in a prospective cohort of African adults shortly after HIV infection. Viral ...
Live attenuated varicella-zoster virus vaccine does not induce HIV target cell activation.
(BMC, 2019-02-01)
BACKGROUND:
Varicella-zoster virus (VZV) is under consideration as a promising recombinant viral vector to deliver foreign antigens including HIV. However, new vectors have come under increased scrutiny, since trials with ...
The effects of aflatoxin exposure on Hepatitis B-vaccine induced immunity in Kenyan children.
(Elsevier, 2019-05)
BACKGROUND:
Globally, approximately three million children die each year from vaccine preventable infectious diseases mainly in developing countries. Despite the success of the expanded immunization program, not all infants ...
First-in-Human Evaluation of the Safety and Immunogenicity of an Intranasally Administered Replication-Competent Sendai Virus-Vectored HIV Type 1 Gag Vaccine: Induction of Potent T-Cell or Antibody Responses in Prime-Boost Regimens.
(2017-01-01)
We report the first-in-human safety and immunogenicity assessment of a prototype intranasally administered, replication-competent Sendai virus (SeV)-vectored, human immunodeficiency virus type 1 (HIV-1) vaccine.
METHO ...
Global Distribution of Human Protoparvoviruses
(BMC, 2018-07-07)
Development of next-generation sequencing and metagenomics has revolutionized detection of novel viruses. Among these viruses are 3 human protoparvoviruses: bufavirus, tusavirus, and cutavirus. These viruses have been ...
Development of a luciferase based viral inhibition assay to evaluate vaccine induced CD8 T-cell responses.
(Universty of Nairobi, 2013-11)
Emergence of SIV and HIV specific CD8 T cells has been shown to correlate with control of in vivo replication. Poor correlation between IFN-γ ELISPOT responses and in vivo control of the virus has triggered the development ...
Cytokine and chemokine expression profiles in response to Mycobacterium tuberculosis stimulation are altered in HIV-infected compared to HIV-uninfected subjects with active tuberculosis.
(University of Nairobi, 2015-05-22)
Mycobacterium tuberculosis (Mtb) infects nearly 2 million people annually and is the most common cause of death in HIV-infected individuals. Tuberculosis (TB) diagnostics cater to HIV-uninfected individuals in non-endemic ...
Recombination following superinfection by HIV-1.
(University of nairobi, 2004)
Background: There is increasing recognition of recombinant HIV-1 strains globally, but it has been unclear whether recombination results from superinfection during untreated, chronic infection.
Objective: To search for ...
Dynamics of viremia in primary HIV-1 infection in Africans: Insights from analyses of host and viral correlates.
(University of Nairobi, 2014)
In HIV-1 infection, plasma viral load (VL) has dual implications for pathogenesis and public health. Based on well-known patterns of HIV-1 evolution and immune escape, we hypothesized that VL is an evolving quantitative ...