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Now showing items 61-70 of 107
Acute-Phase Response Proteins Are Overexpressed in Vaginal Mucosa and Plasma of HIV-Resistant Women upon Viral Challenge
(University of Nairobi, 2013)
Background: The primary receptive portals of entry for HIV are
through mucosal surfaces. Our previous studies show that HIVexposed
uninfected individuals (HESN) have unique innate responses
associated with resistance ...
CD161 identifies polyfunctional Th1/Th17 cells in the genital mucosa that are depleted in HIV-infected female sex workers from Nairobi, Kenya.
(University of Nairobi, 2017)
CD161 identifies a subset of circulating Th17 cells that are depleted in the blood and gut of HIV-infected individuals. In the female reproductive tract (FRT), the pattern of CD161 expression on CD4+ cells remains unknown. ...
Association of Chlamydia trachomatis Heat-Shock Protein 60 Antibody and HLA Class II DQ Alleles
(1999)
A total of 113 female commercial sex workers had individual alleles for HLA class II genes determined by using labeled sequence-specific oligonucleotide probes to hybridize to polymerase chain reaction products of amplified ...
Recombination following superinfection by HIV-1.
(University of nairobi, 2004)
Background: There is increasing recognition of recombinant HIV-1 strains globally, but it has been unclear whether recombination results from superinfection during untreated, chronic infection.
Objective: To search for ...
Association of sex work with reduced activation of the mucosal immune system
(University of Nairobi, 2014-01)
Background. Unprotected intercourse and seminal discharge are powerful activators of the mucosal immune system and are an important risk factors for HIV transmission. This study was designed to determine if female sex work ...
Construction of an infectious HIV type 1 molecular clone from an African patient with a subtype D/C Recombinant Virus.
(2004)
The majority of HIV-1 infections worldwide occur in Africa, where subtype B viruses are rare and intersubtype recombinants are common. Pathogenesis and vaccine studies need to focus on viruses derived from African patients, ...
Genetic diversity and mosaicism at the por locus of Neisseria gonorrhoeae.
(1999)
The por genes of the predominant serovars of Neisseria gonorrhoeae circulating in a high-frequency transmitter core group located in Nairobi, Kenya, were examined for nucleotide sequence polymorphism. The level of por gene ...
Too young to take over: - the hidden face of HIV/AIDS : orphans and vulnerable children from a Kenyan perspective
(University of Nairobi, 2004)
Mucosal Neisseria gonorrhoeae coinfection during HIV acquisition is associated with enhanced systemic HIV-specific CD8 T-cell responses
(2008)
Background: The host immune response against mucosally acquired pathogens may be
influenced by the mucosal immune milieu during acquisition. As Neisseria gonorrhoeae
can impair dendritic cell and T-cell immune function, ...
Reduced rates of HIV acquisition during unprotected sex by Kenyan female sex wo kers predating population declines in H IV prevalence
(2008)
OBJECTIVES:
Female sex workers (FSWs) form a core group at high risk of both sexual HIV acquisition and secondary transmission. The magnitude of these risks may vary by sexual risk taking, partner HIV prevalence, host ...