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Now showing items 31-40 of 107
The role of chlamydia trachomatis in high-risk human papillomavirus persistence among female sex workers in Nairobi, Kenya.
(University of Nairobi, 2015)
BACKGROUND:
Little is known about risk factors for persistent high-risk human papillomavirus (hrHPV) infection in low-income settings, and prior research has not quantified the relative duration of hrHPV infections ...
Characterization of CD8+ T Cell Epitopes Recognizing HIV-1 Epitope Variants
(University Of Nairobi, 2011)
Background: One major challenge in the creation of an HIV-1
vaccine is the extreme genetic diversity of the virus. It is thought
that a more cross-reactive T-cell response would be beneficial in
circumventing this issue. ...
Assessment of the Feasibility of a Different HIV Vaccine Approach
(University Of Nairobi, 2011)
Background: The failure of Merck STEP and Phambili trials and
the modest effect of RV144 trial emphasize the importance of
understanding the correlates of protective immunity. Our study
showed that the epitope recognition ...
Randomized trial of periodic presumptive treatment with high-dose intravaginal metronidazole and miconazole to prevent vaginal infections in HIV-negative women.
(University of Nairobi, 2014)
BACKGROUND:
Vaginal infections are common, frequently recur, and may increase women's risk for sexually transmitted infections (STIs). We tested the efficacy of a novel regimen to prevent recurrent vaginal infections ...
Reducing IRF-1 to levels observed in HESN subjects limits HIV replication, but not the extent of Host immune activation.
(University of Nairobi, 2015-10)
Cells from women who are epidemiologically deemed resistant to HIV infection exhibit a 40–60% reduction in endogenous IRF-1
(interferon regulatory factor-1), an essential regulator of host antiviral immunity and the early ...
Cohorts for the study of HIV-1—exposed but uninfected individuals: benefits and limitations
(Univerisyt of Nairobi, 2010)
Since the late 1980s, with the first identification of individuals who were exposed to human immunodeficiency virus type 1 (HIV-1) yet remained uninfected, or “HIV-1—resistant” individuals, a large number of cohorts that ...
Characterization of a human cervical CD4+ T cell subset coexpressing multiple markers of HIV susceptibility
(2011)
The HIV pandemic disproportionately affects women, with most infections acquired through receptive vaginal sex. Although the target cells by which HIV establishes infection in the female genital tract remain poorly defined, ...
Low dose erythromycin regimen for the treatment of chancroid
(1995)
Haemophilus ducreyi is the commonest cause of genital ulcer disease in Africa and is associated with heterosexual transmission of human immunodeficiency virus(HIV). The World Health Organization currently recommends ...
Influence of HLA Class I Haplotypes on HIV-1 Seroconversion and Disease Progression in Pumwani Sex Worker Cohort.
(University of Nairobi, 2014-07)
We examined the effect of HLA class I haplotypes on HIV-1 seroconversion and disease progression in the Pumwani sex worker cohort. This study included 595 HIV-1 positive patients and 176 HIV negative individuals. HLA-A, ...
Resistance to HIV-1 infection among persistently seronegative prostitutes in Nairobi, Kenya
(1996)
BACKGROUND:
There is indirect evidence that HIV-1 exposure does not inevitably lead to persistent infection. Heterogeneity in susceptibility to infection could be due to protective immunity. The objective of this study ...