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Now showing items 21-30 of 107
Optimizing viable leukocyte sampling from the female genital tract for clinical trials: an international multi-site study
(University of Nairobi, 2014)
BACKGROUND:
Functional analysis of mononuclear leukocytes in the female genital mucosa is essential for understanding the immunologic effects of HIV vaccines and microbicides at the site of HIV exposure. However, the ...
Cross-clade CD8(+) T-cell responses with a preference for the predominant circulating clade
(University of Nairobi, 2005-11)
Human immunodeficiency virus (HIV) genetic diversity is a major impediment to the design of a successful vaccine. Even if an HIV vaccine is proven effective, it remains to be seen whether this protection will extend to ...
CD8(+) Lymphocytes Respond To Different Hiv Epitopes In Seronegative And Infected Subjects.
(University of Nairobi, 2001-02)
HIV-1-specific cytotoxic T-lymphocyte (CTL) responses have been detected at a low frequency in many HIV-1-exposed, persistently seronegative (HEPS) subjects. However, it is unclear how CTLs could protect against HIV ...
Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial.
(2010)
BACKGROUND:
Mobile (cell) phone communication has been suggested as a method to improve delivery of health services. However, data on the effects of mobile health technology on patient outcomes in resource-limited ...
Using safe, affordable and accessible non-steroidal anti-inflammatory drugs to reduce the number of HIV target cells in the blood and at the female genital tract.
(University of Nairobi, 2018)
INTRODUCTION:
At its basic level, HIV infection requires a replication-competent virus and a susceptible target cell. Elevated levels of vaginal inflammation has been associated with the increased risk of HIV infection ...
High-risk HPV-RNA screening of physician- and self-collected specimens for detection of cervical lesions among female sex workers in Nairobi, Kenya.
(University of Nairobi, 2018)
OBJECTIVE:
To compare accuracy of detecting high-grade cervical lesions (squamous intraepithelial lesions or greater, HSIL+) by high-risk HPV messenger RNA (hrHPV-RNA) testing between physician- and self-collected ...
Human Leucocyte Antigen Supertypes And Immune Susceptibility To Hiv-1, Implications
(University of Nairobi, 2001-11-01)
The HAART cell phone adherence trial (WelTel Kenya1): a randomized controlled trial protocol.
(University of Nairobi,, 2009-09)
BACKGROUND:
The objectives are to compare the effectiveness of cell phone-supported SMS messaging to standard care on adherence, quality of life, retention, and mortality in a population receiving antiretroviral therapy ...
Early HIV-1 Infection Is Associated With Reduced Frequencies of Cervical Th17 Cells.
(2015)
BACKGROUND::
The hallmark of HIV infection is progressive but variable rates of systemic and mucosal CD4 depletion, leading to immunodeficiency. The impact of early HIV infection on cervical CD4 T-cell populations in ...
The Expression Analysis of Glucose Transporter 1 Gene in the Pumwani Commercial Sex Worker Cohort, Nairobi, Kenya
(University of Nairobi, 2013)
Background:
Altered susceptibility to HIV1 infection has been
observed in multiple cohort studies. One of the best characterized
HIV1 exposed yet uninfected groups is a commercial sex worker
cohort from Nairobi, Kenya. ...