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Herpes Simplex Virus Type 2, Genital Ulcers and HIV-1 Disease Progression in Postpartum Women
(2011)
Background
Co-infection with herpes simplex virus type 2 (HSV-2) has been associated with increased HIV-1 RNA levels and immune activation, two predictors of HIV-1 progression. The impact of HSV-2 on clinical outcomes ...
Maternal Human Leukocyte Antigen - A*2301 Is Associated with Increased Mother-to-Child HIV-1 Transmission
(2010)
We examined associations between maternal HLA and vertical HIV-1 transmission in a perinatal cohort of 277 HIV-infected women in Nairobi. HLA class I genes were amplified using sequence-specific oligonucleotide probes and ...
Infant Safety during and after Maternal Valacyclovir Therapy in Conjunction with Antiretroviral HIV-1 Prophylaxis in a Randomized Clinical Trial
(2012)
Background
Maternal administration of the acyclovir prodrug valacyclovir is compatible with pregnancy and breastfeeding. However, the safety profile of prolonged infant and maternal exposure to acyclovir in the context ...
Establishing and sustaining a healthy vaginal environment:
(2011)
Data from a randomized trial of oral periodic presumptive
treatment (PPT) to reduce vaginal infections were analyzed
to assess the effect of the intervention on a healthy vaginal
environment (normal flora confirmed by ...
The detection of cytomegalovirus DNA in maternal plasma is associated with mortality in HIV-1 infected women and their infants
(2009)
Objective—Cytomegalovirus (CMV) is an important pathogen in healthy neonates and individuals
with human immunodeficiency virus (HIV-1). The objective of this study was to determine whether
the detection of CMV DNA (CMV ...
Latent TB detection by interferon gamma release assay (IGRA) in pregnancy predicts active TB and mortality in HIV-1 infected women and their children
(2010)
Background—We evaluated the prognostic utility of interferon-gamma release assays (IGRAs)
for active tuberculosis (TB) and mortality in Kenyan HIV-1 infected women and their infants.
Methods—Prevalence and correlates of ...
Effects of Valcyclovir on markers of disease Progression in Postpartum Women Co-Infected with HIV-1 andHerpes Simplex Virus-2
(2012-06)
Objective:
Herpes simplex virus type 2 (HSV-2) suppression has been shown to reduce HIV-1 disease progression in nonpregnant
women and men, but effects on pregnant and postpartum women have not been described.
Methods:
We ...
Predictors of early mortality in a cohort of human immunodeficiency virus Type 1-infected African Children
(2004)
Background: Pediatric human immunodeficiency virus type 1
(HIV-1) infection follows a bimodal clinical course with rapid
progression in 10–45% of children before the age of 2 years and
slower progression in the remainder. ...
Hormonal contraception and HIV-1 disease progression among postpartum Kenyan women
(2007)
Objective
To assess the immediate and longer-term effects of the use of hormonal contraception on the progression of HIV-1 disease in postpartum women.
Design
A prospective cohort study.
Methods
Information on ...
Cost effectiveness of couple counselling to enhance infant HIV-1 prevention
(2008)
Data collected in the years 2001–2003 from an antenatal clinic in Nairobi, Kenya, were used to assess the benefit of couple counselling and test it as a way of increasing the uptake of interventions in the prevention of ...