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Epitope Mapping of HIV-Specific CD8+ T cells in a Cohort Dominated by Clade A1 Infection
(2009)
Background
CD8+ T cell responses are often detected at large magnitudes in HIV-infected subjects, and eliciting these responses is the central aim of many HIV-1 vaccine strategies. Population differences in CD8+ T cell ...
Clade specific evolution mediated by HLA-B*57/5801 in human immunodeficiency virus type 1 Clade A1 p24
(2009)
HLA-B*57-mediated selection pressure leads to a typical escape pathway in human immunodeficiency virus
type 1 (HIV-1) CD8 epitopes such as TW10. Whether this T242N pathway is shared by all clades remains
unknown. We ...
The HAART cell phone adherence trial (WelTel Kenya1): a randomized controlled trial protocol
(2009)
Background
The objectives are to compare the effectiveness of cell phone-supported SMS messaging to standard care on adherence, quality of life, retention, and mortality in a population receiving antiretroviral therapy ...
Human Immunodeficiency Virus (HIV) Type 1 Proviral Hypermutation Correlates with CD4 Count in HIV-Infected Women from Kenya[down-pointing small open triangle]
(2008)
APOBEC3G is an important innate immune molecule that causes human immunodeficiency virus type 1 (HIV-1) hypermutation, which can result in detrimental viral genome mutations. The Vif protein of wild-type HIV-1 counteracts ...
Multiplex detection of bacteria associated with normal microbiota and with bacterial vaginosis in vaginal swabs by use of oligonucleotide-coupled fluorescent
(Univerisyt of Nairobi, 2009-12)
Bacterial vaginosis (BV) is a recurrent condition that is associated with a range of negative outcomes, including the acquisition of human immunodeficiency virus and other sexually transmitted diseases, preterm births, and ...
A common HLA-DP genotype is associated with resistance to hiv-1 infection in Kenyan sex workers
(Univerisyt of Nairobi, 2008-10)
HLA-DP antigens present peptides to CD4+ T cells and play an important role in parasitic infections and autoimmune diseases, yet their influence on HIV-1 susceptibility has not been well studied. Here, we report several ...
A common CD4 gene variant Is associated with an increased risk of HIV-1 infection in Kenyan female commercial sex workers
(2009)
It has been predicted that CD4 C868T, a novel CD4 single-nucleotide polymorphism (SNP) that has
been found to be highly prevalent among Africans, changes the tertiary structure of CD4, which may alter susceptibility to ...
The HAART cell phone adherence trial (WelTel Kenya1): a randomized controlled trial protocol
(2009)
The objectives are to compare the effectiveness of cell phone-supported SMS
messaging to standard care on adherence, quality of life, retention, and mortality in a population
receiving antiretroviral therapy (ART) in ...
Functional HIV-1 specific IgA antibodies in HIV-1 exposed, persistently IgG seronegative female sex workers
(2001-11)
Although HIV-specific cellular immune responses are found in a number of HIV highly-exposed, persistently seronegative (HEPS) cohorts, late seroconversion can occur despite pre-existing cytotoxic T lymphocytes (CTL), ...
High Prevalence of Genetically Similar HIV-1 Recombinants among Infected Sex Workers in Nairobi, Kenya
(University of Nairobi, 2008)
HIV-1, a highly diverse infectious agent, shows the greatest sequence diversity in highly exposed individuals, including greater levels of recombination. HIV-1 diversity in Nairobi, Kenya was examined in 240 individuals, ...