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Evaluation of a quantitative real-time PCR assay to measure HIV-specific mucosal CD8+ T Cell responses in the cervix
(2010)
Several candidate HIV vaccines aim to induce virus-specific cellular immunity particularly in the genital tract, typically the
initial site of HIV acquisition. However, standardized and sensitive methods for evaluating ...
Blunted IL17/IL22 and pro-inflammatory cytokine responses in the genital tract and blood of HIV Exposed, seronegative female sex workers in Kenya
(2012)
Identifying the immune correlates of reduced susceptibility to HIV remains a key goal for the HIV vaccine field, and individuals who are HIV-exposed, seronegative (HESN) may offer important clues. Reduced systemic immune ...
HIV-1 Clade D Is Associated with Increased Rates of CD4 Decline in a Kenyan Cohort
(2012)
HIV-1 is grouped phylogenetically into clades, which may impact rates of HIV-1 disease progression. Clade D infection in
particular has been shown to be more pathogenic. Here we confirm in a Nairobi-based prospective ...
HIV viral set point and host immune control in individuals with HIV-specific CD8R T-cell responses prior to HIV acquisition
(2010)
OBJECTIVE:
Vaccine-induced CD8(+) T-cell responses in primates have been associated with a reduced simian immunodeficiency virus plasma viral load and enhanced T-cell responses, but cellular vaccines have shown limited ...