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Infant CD4 C868T polymorphism is associated with increased human immunodeficiency virus (HIV-1) acquisition

Choi, RY; Farquhar, C; Juno, J; Mbori-Ngacha, DA; Lohman-Payne, B; Vouriot, F; Wayne, S; Tuff, J; Bosire, R; John-Stewart, G; Fowke, K (University of Nairobi., 2010-06)

The C868T single nucleotide polymorphism (SNP) in the CD4 receptor encodes an amino acid change that could alter its structure and influence human immunodeficiency virus (HIV-1) infection risk. HIV-1-infected pregnant women ...

Predictors of mortality in HIV-1 infected children on antiretroviral therapy in Kenya:

Wamalwa, Dalton C; Obimbo, Elizabeth M; Farquhar, Carey; Richardson, Barbra A; Mbori-Ngacha, DA; Inwani, Irene; Benki-Nugent, Sara; John-Stewart, Grace (2010)

Background: Among children, early mortality following highly active antiretroviral therapy (HAART) remains high. It is important to define correlates of mortality in order to improve outcome. Methods: HIV-1-infected ...

Maternal Human Leukocyte Antigen - A*2301 Is Associated with Increased Mother-to-Child HIV-1 Transmission

Mackelprang, Romel D; Carrington, Mary; John-Stewart, Grace; Lohman-Payne, Barbara; Richardson, Barbra A; Wamalwa, Dalton; Gao, Xiaojiang; Majiwa, Maxwel; Mbori-Ngacha, DA; Farquhar, Carey (2010)

We examined associations between maternal HLA and vertical HIV-1 transmission in a perinatal cohort of 277 HIV-infected women in Nairobi. HLA class I genes were amplified using sequence-specific oligonucleotide probes and ...

Cofactors for HIV-1 incidence during pregnancy and postpartum period.

Kinuthia, J; Kiarie, JN; Farquhar, C; Richardson, B; Nduati, RW; Mbori-Ngacha, DA; John-Stewart, G (2010-10)

OBJECTIVES: to estimate HIV-1 incidence and cofactors for HIV-1 incidence during pregnancy and postpartum. DESIGN: retrospective study among women who were HIV seronegative during pregnancy. METHODS: mothers ...

Latent TB detection by interferon gamma release assay (IGRA) in pregnancy predicts active TB and mortality in HIV-1 infected women and their children

Jonnalagadda, Sasi; Payne, Barbara Lohman; Brown, Elizabeth; Wamalwa, Dalton; Obimbo, Elizabeth Maleche; Majiwa, Maxwel; Farquhar, Carey; Otieno, Phelgona; Mbori-Ngacha, DA; John-Stewart, Grace (2010)

Background—We evaluated the prognostic utility of interferon-gamma release assays (IGRAs) for active tuberculosis (TB) and mortality in Kenyan HIV-1 infected women and their infants. Methods—Prevalence and correlates of ...

Illness during pregnancy and bacterial vaginosis are associated with in-utero HIV-1 transmission

Farquhar, C; Mbori-Ngacha, DA; Overbaugh, J; Wamalwa, D; Harris, J; Bosire, R; John-Stewart, G (University of Nairobi., 2010-01)

HIV-1 transmission in utero accounts for 20-30% of vertical transmission events in breast-feeding populations. In a prospective study of 463 HIV-1-infected mothers and infants, illness during pregnancy was associated with ...

Cofactors for HIV-1 Incidence during Pregnancy and Postpartum Period

Kinuthia, John; Kiarie, James N; Farquhar, Carey; Richardson, Barbra; Nduati, RW; Mbori-Ngacha, DA; John-Stewart, Grace (2010)

Objectives To estimate HIV-1 incidence and cofactors for HIV-1 incidence during pregnancy and postpartum. Design Retrospective study among women who were HIV seronegative during pregnancy. Methods Mothers ...