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HIV-1 Env-specific cytotoxic T-lymphocyte responses in exposed, uninfected Kenyan sex workers: a prospective analysis.
(University of Nairobi, 2004-10-21)
The prospective significance of HIV-specific cytotoxic T lymphocyte (CTL) responses in highly exposed, persistently seronegative populations is unknown. In 1996-1997 we screened for CTL responses against HIV clade B Env ...
High pH reversed-phase chromatography as a superior fractionation scheme compared to off-gel isoelectric focusing for complex proteome analysis
(University of Nairobi, 2013-10)
MS/MS is the technology of choice for analyzing complex protein mixtures. However, due to the intrinsic complexity and dynamic range present in higher eukaryotic proteomes, prefractionation is an important step to maximize ...
Presumptive specific clinical diagnosis of genital ulcer disease (GUD) in a primary health care setting in Nairobi.
(1996)
Of 22,274 patients 12 years of age or older attending a primary health care clinic in Nairobi, 1076 (4.8%) complained of symptoms suggesting a sexually transmitted disease (STD). Of these, 518 females and 462 males underwent ...
Increased interleukin-10 in the the endocervical secretions of women with non-ulcerative sexually transmitted diseases: a mechanism for enhanced HIV-1 transmission?
(1999)
OBJECTIVE:
Although non-ulcerative sexually transmitted diseases (STD) and bacterial vaginosis are implicated as cofactors in heterosexual HIV-1 transmission, the mechanisms have not been defined. Recent in vitro data ...
Molecular Definition Of Vaginal Microbiota In East African Commercial Sex Workers
(University of Nairobi, 2011-06)
Resistance to HIV infection in a cohort of commercial sex workers living in Nairobi, Kenya, is linked to mucosal and antiinflammatory factors that may be influenced by the vaginal microbiota. Since bacterial vaginosis (BV), ...
Relative HIV Resistance In Kenyan Sex Workers Is Not Due To An Altered Prevalence Or Mucosal Immune Impact Of Herpes Simplex Virus Type 2 Infection.
(University of Nairobi, 2009-09)
Chronic infection by herpes simplex virus type 2 (HSV-2) increases HIV susceptibility, perhaps due to HSV-2-associated increases in activated mucosal immune cells. A small number of Kenyan female sex workers (FSWs) exhibit ...
A Comparison Of Parallel Pyrosequencing And Sanger Clone-based Sequencing And Its Impact On The Characterization Of The Genetic Diversity Of Hiv-1.
(University of Nairobi, 2011)
BACKGROUND:
Pyrosequencing technology has the potential to rapidly sequence HIV-1 viral quasispecies without requiring the traditional approach of cloning. In this study, we investigated the utility of ultra-deep ...