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Now showing items 3911-3920 of 3953
Emergence of Clinical Clostridioides difficile Isolates With Decreased Susceptibility to Vancomycin
(University of Nairobi, 2022-01)
Background: Clostridioides difficile infection (CDI) is a leading cause of hospital-associated antibiotic-related diarrhea and deaths worldwide. Vancomycin is one of the few antibiotics recommended for both nonsevere and ...
Pediatric saliva-based HIV testing: healthcare worker and caregiver acceptability
(University of Nairobi, 2022-04)
Background: Pediatric HIV testing remains suboptimal. The OraQuick test (saliva-based test [SBT]) is validated in pediatric populations ≥18 months. Understanding caregiver and healthcare worker (HCW) acceptability of ...
Community-based lifestyle intervention improves metabolic syndrome and related markers among Kenyan adults
(University of Nairobi, 2022-03)
Purpose: Metabolic syndrome (MetS) is a major risk factor for cardiovascular diseases and type-2 diabetes. The study aimed to establish the efficacy of a community-based lifestyle intervention on MetS in Kenyan adults using ...
Prevalence of esophageal squamous dysplasia in relatives of patients with esophageal cancer in Southwestern Kenya
(University of Nairobi, 2022-06)
Background: Esophageal squamous cell carcinoma (ESCC) and its asymptomatic precursor lesion, esophageal squamous dysplasia (ESD), are common in East Africa. It is unknown whether family history of esophageal cancer is a ...
Microbiological contamination of herbal medicinal products marketed in Kenya for chronic diseases: A case study of Nairobi metropolis
(Elsevier, 2021-10)
Herbal medicines’ use is steadily increasing globally, thus creating a compelling need for quality assurance. The present study assessed the microbial contamination of 86 herbal preparations marketed in the Nairobi metropolis ...
Constituents of Croton Megalocarpus With Potential Anti-hiv Activity
(University of Nairobi, 2022)
Reported herein is an anti-HIV monochlorinated compound, 1β-acetoxy-3β-chloro-5α,6α-dihydroxycrotocascarin L (1), of the rare crotofolane diterpenoid class. Compound 1, a suspected artifact of extraction, along with the ...
Psychological Experiences of Caregivers of Adolescents Diagnosed With Substance Use Disorder Attending a Youth Centre in a Low-resource Setting
(University of Nairobi, 2022)
Caregivers, whether a biological parent, adoptive parent, or a relative such as a grandparent, of adolescent with substance use disorder (SUD) undergo immense psychological and social strains, as they have to deal with ...
Progress on the national action plan of Pakistan on antimicrobial resistance (AMR): a narrative review and the implications
(University of Nairobi, 2022-01)
Introduction: The emergence of antimicrobial resistance (AMR) is a threat to public health. In 2015, the World Health Organization (WHO) introduced a global action plan to tackle AMR in the World Health Assembly. Pakistan's ...
Pairwise Joint Modeling of Clustered and High-dimensional Outcomes With Covariate Missingness in Pediatric Pneumonia Care
(University of Nairobi, 2022)
Multiple outcomes reflecting different aspects of routine care are a common phenomenon in health care research. A common approach of handling such outcomes is multiple univariate analyses, an approach which does not allow ...
Potential pharmacologic interventions targeting TLR signaling in placental malaria
(University of Nairobi, 2022)
Complications from placental malaria cause poor pregnancy outcomes, including low birthweight, preterm delivery, and stillbirths. Many of these complications are driven by maternal innate proinflammatory responses to the ...