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Immune Quiescence: a model of protection against HIV infection
(2013-11-20)
Abstract
Aberrant immune activation is a strong correlate of HIV disease progression, but little is known about how immune activation alters susceptibility to HIV infection. Susceptibility to HIV infection varies between ...
Epitope Mapping of HIV-Specific CD8+ T cells in a Cohort Dominated by Clade A1 Infection
(2009)
Background
CD8+ T cell responses are often detected at large magnitudes in HIV-infected subjects, and eliciting these responses is the central aim of many HIV-1 vaccine strategies. Population differences in CD8+ T cell ...
Genetic analysis of human DNA recovered from minute amounts of serum or plasma
(University of Nairobi, 1995-03-13)
A rapid and inexpensive method is described where a small amount of serum or plasma was used as the source of DNA for genetic analysis. Using a silica gel matrix DNA was isolated from 50 μl of archived serum or plasma. The ...
The role of G protein gene GNB3 C825T Polymorphism in HIV-1 acquisition, progression and immune activation
(2012)
Background
The GNB3 C825T polymorphism is associated with increased G protein-mediated signal transduction, SDF-1α-mediated lymphocyte chemotaxis, accelerated HIV-1 progression, and altered responses to antiretroviral ...
Epitope cross-reactivity frequently differs between central and effector memory HIV-specific CD8+ t cells1
(Univerisyt of Nairobi, 2007-03)
HIV diversity may limit the breadth of vaccine coverage due to epitope sequence differences between strains. Although amino acid substitutions within CD8+ T cell HIV epitopes can result in complete or partial abrogation ...
Reduced Cellular Susceptibility to In Vitro HIV Infection Is Associated with CD4+ T Cell Quiescence
(2012)
Background
HIV preferentially establishes productive infection in activated CD4+ T cells. Since proportions of activated CD4+ T cells vary between individuals, this study aimed to determine if individuals with a greater ...
Elevated expression of LAG-3, but not PD-1, is associated with impaired iNKT cytokine production during chronic HIV-1 infection and treatment
(University of Nairobi, 2015)
Background:
LAG-3 is a potent negative regulator of the immune response but its impact in HIV infection in
poorly understood. Unlike exhaustion markers such as PD-1, Tim-3, 2B4 and CD160, LAG-3 is poorly expressed on
bulk ...
Enrichment of LAG-3, but not PD-1, on Double Negative T Cells at the Female Genital Tract
(University of Nairobi, 2014-12)
Problem
The expression of inhibitory markers such as LAG-3 and PD-1 on T lymphocytes regulates immune function. Their expression at the genital mucosa is poorly understood, but regulation of immune activation at the ...
The impact of sex work interruption on blood-derived t cells in sex workers from Nairobi, Kenya
(University of Nairobi, 2016)
Background: Unprotected sexual intercourse exposes the female genital tract (FGT) to semen-derived antigens, which leads to a proinflammatory response. Studies have shown that this postcoital inflammatory response can lead ...