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Identification and characterization of HLA-A*0301 epitopes in HIV-1 gag proteins using a novel approach
(2010-01)
Identification of CTL epitopes correlated to immune protection is important for the development of vaccines that enhance T-cell mediated immune responses. The correlation of positively selected amino acids (PS) of HIV-1 ...
Bacterial vaginosis, HIV serostatus and T-cell subset distribution in a cohort of East African commercial sex workers: retrospective analysis
(2012)
Although bacterial vaginosis is a known correlate of HIV infection, no previous studies have investigated whether women defined as HIV-exposed seronegative (HESN) are less likely to have bacterial vaginosis. Little is known ...
HIV-Exposed seronegative commercial sex workers show a quiescent phenotype in the CD4+ T cell compartment and reduced expression of HIV-dependent host factors
(2010)
Studies of human immunodeficiency virus (HIV)–exposed seronegative individuals are crucial to informvaccine
design. In the present study we demonstrated that HIV-exposed seronegative commercial sex workers produce
lower ...
Clade specific evolution mediated by HLA-B*57/5801 in human immunodeficiency virus type 1 Clade A1 p24
(2009)
HLA-B*57-mediated selection pressure leads to a typical escape pathway in human immunodeficiency virus
type 1 (HIV-1) CD8 epitopes such as TW10. Whether this T242N pathway is shared by all clades remains
unknown. We ...
Evaluation of a quantitative real-time PCR assay to measure HIV-specific mucosal CD8+ T Cell responses in the cervix
(2010)
Several candidate HIV vaccines aim to induce virus-specific cellular immunity particularly in the genital tract, typically the
initial site of HIV acquisition. However, standardized and sensitive methods for evaluating ...
New insights into HIV-1 specific cytotoxic T-lymphocyte responses in exposed, persistently seronegative Kenyan sex workers
(2001)
A clearer understanding of HIV-1 specific immune responses in highly-exposed, persistently seronegative (HEPS) subjects is important in developing models of HIV-1 protective immunity. HIV-1 specific cytotoxic T-lymphocytes ...
Bacterial vaginosis in HIV-infected women induces reversible alterations in the cervical immune environment
(2008)
Bacterial vaginosis (BV) has been associated with
increased HIV cervicovaginal shedding. We hypothesized that this might relate to BV-associated increases in mucosal activated CD4+ T cells, which could enhance local HIV ...
Blunted IL17/IL22 and pro-inflammatory cytokine responses in the genital tract and blood of HIV Exposed, seronegative female sex workers in Kenya
(2012)
Identifying the immune correlates of reduced susceptibility to HIV remains a key goal for the HIV vaccine field, and individuals who are HIV-exposed, seronegative (HESN) may offer important clues. Reduced systemic immune ...
A common CD4 gene variant Is associated with an increased risk of HIV-1 infection in Kenyan female commercial sex workers
(2009)
It has been predicted that CD4 C868T, a novel CD4 single-nucleotide polymorphism (SNP) that has
been found to be highly prevalent among Africans, changes the tertiary structure of CD4, which may alter susceptibility to ...
Negative mucosal synergy between Herpes simplex type 2 and HIV in the female genital tract
(2007)
There is substantial epidemiological evidence that infection by Herpes simplex virus type 2 (HSV2) enhances both HIV susceptibility and subsequent sexual transmission. Both infections are extremely common in female sex ...