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Resistance to HIV-1 infection among African sex workers is associated with global hyporesponsiveness in interleukin 4 production.
(2001)
We previously identified HIV-1 resistant prostitutes who remain persistently HIV-1 PCR- and
antibody-negative despite continued heavy exposure to HIV-1 through sex work. We hypothesized
that differences in virus-specific ...
Risk factors for postnatal mother-child transmission of HIV-1.
(2000)
OBJECTIVE:
To identify factors affecting HIV-1 breastfeeding transmission.
DESIGN:
Longitudinal observational cohort study.
METHODS:
HIV-1 seropositive pregnant women and seronegative controls were enrolled ...
A randomized, placebo-controlled trial of monthly azithromycin prophylaxis to prevent sexually transmitted infections and HIV-1 in Kenyan sex workers: study design and baseline findings
(2000)
Our objectives were to describe the baseline findings of a trial of antibiotic prophylaxis to prevent sexually transmitted infections (STIs) and HIV-1 in a cohort of Nairobi female sex workers (FSWs). A questionnaire was ...
Acute sexually transmitted infections increase human immunodeficiency virus type 1 plasma viremia, increase plasma type 2 cytokines, and decrease CD4 cell counts
(2000)
In Kenya, the median incubation time to AIDS in seroconverting sex workers is 4 years;
this incubation time is specific to female sex workers.We studied the influence of acute sexually transmitted infections (STIs) on ...
CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects.
(University of Nairobi, 2001-05)
HIV-1-specific cytotoxic T-lymphocyte (CTL) responses have been detected at a low frequency in many HIV-1-exposed, persistently seronegative (HEPS) subjects. However, it is unclear how CTLs could protect against HIV ...
HIV-1 Env-specific cytotoxic T-lymphocyte responses in exposed, uninfected Kenyan sex workers: a prospective analysis.
(University of Nairobi, 2004-10-21)
The prospective significance of HIV-specific cytotoxic T lymphocyte (CTL) responses in highly exposed, persistently seronegative populations is unknown. In 1996-1997 we screened for CTL responses against HIV clade B Env ...
HLA typing in a Kenyan cohort identifies novel class I alleles that restrict cytotoxic T-cell responses to local HIV-1 clades.
(University of Nairobi, 2002-09)
OBJECTIVES:
To investigate HLA class I allele frequencies in a Kenyan commercial sex worker (CSW) cohort, and to examine HIV-1 specific cytotoxic T lymphocyte (CTL) responses directed against epitopes derived from locally ...
Sequence and peptide-binding motif for a variant of HLA-A*0214 (A*02142) in an HIV-1-resistant individual from the Nairobi Sex Worker cohort
(Springer-Verlag, 2001)
As part of the ongoing study of natural HIV-1 resistance in the women of the Nairobi Sex Workers' study, we have examined a resistance-associated HLA class I allele at the molecular level. Typing by polymerase chain reaction ...
Construction of an infectious HIV type 1 molecular clone from an African patient with a subtype D/C Recombinant Virus.
(2004)
The majority of HIV-1 infections worldwide occur in Africa, where subtype B viruses are rare and intersubtype recombinants are common. Pathogenesis and vaccine studies need to focus on viruses derived from African patients, ...
Influence of HLA supertypes on susceptibility and resistance to human immunodeficiency virus type 1 infection.
(, 2000-05)
Certain human leukocyte antigens, by presenting conserved immunogenic epitopes for T cell recognition, may, in part, account for the observed differences in human immunodeficiency virus type 1 (HIV-1) susceptibility. To ...