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Identification and characterization of HLA-A*0301 epitopes in HIV-1 gag proteins using a novel approach
(2010-01)
Identification of CTL epitopes correlated to immune protection is important for the development of vaccines that enhance T-cell mediated immune responses. The correlation of positively selected amino acids (PS) of HIV-1 ...
Bacterial vaginosis, HIV serostatus and T-cell subset distribution in a cohort of East African commercial sex workers: retrospective analysis
(2012)
Although bacterial vaginosis is a known correlate of HIV infection, no previous studies have investigated whether women defined as HIV-exposed seronegative (HESN) are less likely to have bacterial vaginosis. Little is known ...
Epitope Mapping of HIV-Specific CD8+ T cells in a Cohort Dominated by Clade A1 Infection
(2009)
Background
CD8+ T cell responses are often detected at large magnitudes in HIV-infected subjects, and eliciting these responses is the central aim of many HIV-1 vaccine strategies. Population differences in CD8+ T cell ...
Effect of Baseline HIV Disease Parameters on CD4+ T Cell Recovery After Antiretroviral Therapy Initiation in Kenyan Women
(2010)
Background
Antiretroviral therapy (ART) for HIV infection reconstitutes the immune system and improves survival. However, the rate and extent of CD4+ T cell recovery varies widely. We assessed the impact of several ...
HIV-Exposed seronegative commercial sex workers show a quiescent phenotype in the CD4+ T cell compartment and reduced expression of HIV-dependent host factors
(2010)
Studies of human immunodeficiency virus (HIV)–exposed seronegative individuals are crucial to informvaccine
design. In the present study we demonstrated that HIV-exposed seronegative commercial sex workers produce
lower ...
Clade specific evolution mediated by HLA-B*57/5801 in human immunodeficiency virus type 1 Clade A1 p24
(2009)
HLA-B*57-mediated selection pressure leads to a typical escape pathway in human immunodeficiency virus
type 1 (HIV-1) CD8 epitopes such as TW10. Whether this T242N pathway is shared by all clades remains
unknown. We ...
Evaluation of a quantitative real-time PCR assay to measure HIV-specific mucosal CD8+ T Cell responses in the cervix
(2010)
Several candidate HIV vaccines aim to induce virus-specific cellular immunity particularly in the genital tract, typically the
initial site of HIV acquisition. However, standardized and sensitive methods for evaluating ...
Feasibility and Safety of Cervical Biopsy Sampling for Mucosal Immune Studies in Female Sex Workers from Nairobi, Kenya
(2012)
Background
There is an urgent need to improve our understanding of the mucosal immuno-pathogenesis of HIV acquisition in the female genital tract, particularly in high-risk women such as female sex workers (FSWs). ...
Repeat use of post exposure prophylaxis for HIV among Nairobi based female sex workers following sexual exposure
(University of Nairobi, 2015-05-13)
As ART-based prevention becomes available, effectively targeting these interventions to key populations such as female sex workers (FSW) will be critical. In this study we analyze patterns of repeated post-exposure prophylaxis ...
Preventing HIV-1 Infection, More Epitope Is Not Better: Analysis of Gag Epitope of 2 HLA Alleles Associated with Different Outcome of HIV Infection
(2012)
Background: Current HIV vaccine candidates have been based on
the conventional views of viral infection and attempt to induce
broad T cell responses to HIV-1. Until now, the candidate vaccines
based on such approach ...