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Human Immunodeficiency Virus (HIV) Type 1 Proviral Hypermutation Correlates with CD4 Count in HIV-Infected Women from Kenya[down-pointing small open triangle]
(2008)
APOBEC3G is an important innate immune molecule that causes human immunodeficiency virus type 1 (HIV-1) hypermutation, which can result in detrimental viral genome mutations. The Vif protein of wild-type HIV-1 counteracts ...
The Expression Analysis of Hexokinase 1 Gene in the Pumwani Commercial Sex Worker Cohort, Nairobi, Kenya
(University of Nairobi, 2014)
Background: Altered susceptibility to HIV-1 infection has been observed in a commercial sex worker (CSW) cohort in Nairobi, Kenya, where a subset of women are classified as HIV-1 exposed yet seronegative (HESN). A gene ...
Prevention of mother-to-child transmission of HIV in Kenya: challenges to implementation
(2014)
Background
The prevention of mother-to-child transmission of human immunodeficiency virus (HIV) is lauded as one of the more successful HIV prevention measures. However, despite some gains in the prevention of mother-to-child ...
Donating human samples: who benefits? Cases from iceland, Kenya and Indonesia
(Univerisyt of Nairobi, 2013-06)
Benefit sharing involving human genetic resources is an unresolved topic. Some argue that participation in scientific research should always be altruistically motivated, which is how access to human genetic resources has ...
Blunted il17/il22 and pro-inflammatory cytokine responses in the genital tract and blood of HIV-exposed, seronegative female sex workers in Kenya
(Univerisyt of Nairobi, 2012-08)
Background
Identifying the immune correlates of reduced susceptibility to HIV remains a key goal for the HIV vaccine field, and individuals who are HIV-exposed, seronegative (HESN) may offer important clues. Reduced ...
Evaluation of a quantitative real-time PCR assay to measure HIV-specific mucosal CD8+ T cell responses in the cervix
(Univerisyt of Nairobi, 2010-10)
Several candidate HIV vaccines aim to induce virus-specific cellular immunity particularly in the genital tract, typically the initial site of HIV acquisition. However, standardized and sensitive methods for evaluating ...
Multiplex detection of bacteria associated with normal microbiota and with bacterial vaginosis in vaginal swabs by use of oligonucleotide-coupled fluorescent
(Univerisyt of Nairobi, 2009-12)
Bacterial vaginosis (BV) is a recurrent condition that is associated with a range of negative outcomes, including the acquisition of human immunodeficiency virus and other sexually transmitted diseases, preterm births, and ...
A common HLA-DP genotype is associated with resistance to hiv-1 infection in Kenyan sex workers
(Univerisyt of Nairobi, 2008-10)
HLA-DP antigens present peptides to CD4+ T cells and play an important role in parasitic infections and autoimmune diseases, yet their influence on HIV-1 susceptibility has not been well studied. Here, we report several ...
Selection, Phenotyping and Identification of Acid and Hydrogen Peroxide Producing Bacteria from Vaginal Samples of Canadian and East African Women
(2012)
The common but poorly understood condition known as bacterial vaginosis (BV) increases vulnerability to HIV infection and is associated with the absence of H(2)O(2)-producing Lactobacillus. Vaginal lactic acid bacteria ...
A common CD4 gene variant Is associated with an increased risk of HIV-1 infection in Kenyan female commercial sex workers
(2009)
It has been predicted that CD4 C868T, a novel CD4 single-nucleotide polymorphism (SNP) that has
been found to be highly prevalent among Africans, changes the tertiary structure of CD4, which may alter susceptibility to ...