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Safety and Immunogenicity Study of Multiclade HIV-1 Adenoviral Vector Vaccine Alone or as Boost following a Multiclade HIV-1 DNA Vaccine in Africa
(University of nairobi, 2010)
Abstract
BACKGROUND:
We conducted a double-blind, randomized, placebo-controlled Phase I study of a recombinant replication-defective adenovirus type 5 (rAd5) vector expressing HIV-1 Gag and Pol from subtype B and Env ...
Validity of the vaginal discharge algorithm among pregnant and non-pregnant women in Nairobi, Kenya
(University of Nairobi., 2000-02)
OBJECTIVE:
To evaluate the validity of different algorithms for the diagnosis of gonococcal and chlamydial infections among pregnant and non-pregnant women consulting health services for vaginal discharge in Nairobi, ...
Bacterial vaginosis, HIV serostatus and T-cell subset distribution in a cohort of East African commercial sex workers: retrospective analysis
(2012)
Although bacterial vaginosis is a known correlate of HIV infection, no previous studies have investigated whether women defined as HIV-exposed seronegative (HESN) are less likely to have bacterial vaginosis. Little is known ...
A simple and quick method for enhanced detection of specific IgE in serum from lymphatic filariasis patients
(2001)
A new simple and quick technique, using a suspension of protein A agarose beads to absorb IgG4 from sera prior
to determination of filarial-specific IgE in ELISA, is presented. The optimal ratio between serum and absorbant ...
Filarial-specific antibody response in East African bancroftian filariasis
(2006)
The effect of host infection, chronic clinical disease, and transmission intensity on the patterns of specific
antibody responses in Bancroftian filariasis was assessed by analyzing specific IgG1, IgG2, IgG3, IgG4, and ...
HIV-Exposed seronegative commercial sex workers show a quiescent phenotype in the CD4+ T cell compartment and reduced expression of HIV-dependent host factors
(2010)
Studies of human immunodeficiency virus (HIV)–exposed seronegative individuals are crucial to informvaccine
design. In the present study we demonstrated that HIV-exposed seronegative commercial sex workers produce
lower ...
Genital inflammation predicts HIV-1 shedding independent of plasma viral load and systemic inflammation
(2012)
In women, genital HIV-1 RNA levels predict the risk of
HIV-1 transmission independent of plasma viral load. To better
understand the factors that contribute to genital HIV-1 shedding, we
evaluated the relationships ...
Evaluation of a quantitative real-time PCR assay to measure HIV-specific mucosal CD8+ T Cell responses in the cervix
(2010)
Several candidate HIV vaccines aim to induce virus-specific cellular immunity particularly in the genital tract, typically the
initial site of HIV acquisition. However, standardized and sensitive methods for evaluating ...
Transmission intensity and the immunoepidemiology of bancroftian filariasis in East Africa
(2001)
Previous attempts to determine the interactions between filariasis transmission intensity, infection and chronic disease have been limited by a lack of a theoretical framework that allows the explicit examination of ...
The prevalence, clinical features, risk factors and outcome associated with cryptococcal meningitis in HIV positive patients in Kenya
(2010)
To determine the prevalence, clinical features, risk factors and outcomes associated with cryptococcal meningitis (CM) in human immunodeficiency virus (HIV) positive patients at two referral hospitals in Nairobi, Kenya ...