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Now showing items 1-10 of 11
A Prospective study of vaginal bacterial flora and other risk factors for vulvovaginal candidiasis
(2009-06)
Background. It has been suggested that vaginal colonization with lactobacilli may reduce the risk of vulvovaginal
candidiasis (VVC), but supporting data are limited. Our objective was to determine the relationship between ...
Breadth of neutralizing antibody response to human immunodeficiency virus type 1 is affected by factors early in infection but does not influence disease progression.
(University of Nairobi, 2009-10)
The determinants of a broad neutralizing antibody (NAb) response and its effect on human immunodeficiency virus type 1 (HIV-1) disease progression are not well defined, partly because most prior studies of a broad NAb ...
Serologic testing algorithm for recent HIV Seroconversion in estimating incidence of HIV-1 among adults visiting a VCT centre at a Kenyan tertiary health institution
(2009-05)
Objective: To determine HIV high risk groups among adults visiting Kenyatta National Hospital Voluntary Counselling and Testing Centre by use of Serologic Testing Algorithm for Recent HIV Seroconversion (STARHS).
Design: ...
Sex, microbial translocation, and the African HIV epidemic
(University of Nairobi, 2009-08)
Redd et al. (1) suggest that microbial translocation is not an important contributor to HIV disease progression in Africa, in contrast to its possible role in HIV pathogenesis in North American cohorts (2–4). They further ...
A common CD4 gene variant Is associated with an increased risk of HIV-1 infection in Kenyan female commercial sex workers
(2009)
It has been predicted that CD4 C868T, a novel CD4 single-nucleotide polymorphism (SNP) that has
been found to be highly prevalent among Africans, changes the tertiary structure of CD4, which may alter susceptibility to ...
Human Immunodeficiency Virus type 1 elite neutralizers:
(2009)
The development of a rapid and efficient system to identify human immunodeficiency virus type 1 (HIV-1)-
infected individuals with broad and potent HIV-1-specific neutralizing antibody responses is an important step
toward ...
Temporal analysis of HIV envelope sequence evolution and antibody escape in a subtype A-infected individual with a broad neutralizing antibody response
(2009)
The origin of broadly neutralizing HIV-specific antibodies and their relation to HIV evolution are not well
defined. Here we examined virus evolution and neutralizing antibody escape in a subtype A infected
individual ...
Relative HIV Resistance In Kenyan Sex Workers Is Not Due To An Altered Prevalence Or Mucosal Immune Impact Of Herpes Simplex Virus Type 2 Infection.
(University of Nairobi, 2009-09)
Chronic infection by herpes simplex virus type 2 (HSV-2) increases HIV susceptibility, perhaps due to HSV-2-associated increases in activated mucosal immune cells. A small number of Kenyan female sex workers (FSWs) exhibit ...
European and Developing Countries Clinical Trials Partnership (EDCTP): the path towards a true partnership.
(University of Nairobi., 2009-07)
BACKGROUND:
European and Developing Countries Clinical Trials Partnership (EDCTP) was founded in 2003 by the European Parliament and Council. It is a partnership of 14 European Union (EU) member states, Norway, Switzerland, ...
Cervical HIV-specific IgA in a population of commercial sex workers correlates with repeated exposure but not resistance to HIV
(2009)
We conducted a comprehensive cross-sectional analysis of total and HIV-specific cervical antibody levels in HIV-
1-resistant, uninfected, and infected women in order to examine the role of HIV-specific antibody responses ...