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Now showing items 21-30 of 37
Dynamics of viremia in primary HIV-1 infection in Africans: Insights from analyses of host and viral correlates.
(University of Nairobi, 2014)
In HIV-1 infection, plasma viral load (VL) has dual implications for pathogenesis and public health. Based on well-known patterns of HIV-1 evolution and immune escape, we hypothesized that VL is an evolving quantitative ...
Mucosal blood group antigen expression profiles and HIV infections A Study among female sex workers in Kenya.
(University of Nairobi, 2015-07)
Background
The ABO blood group antigens are carbohydrate moieties expressed on human red blood
cells however; these antigens can also be expressed on some other cells particularly the
surface of epithelial cells and may ...
Understanding Adherence to Daily and Intermittent Regimens of Oral HIV Pre-exposure Prophylaxis Among Men Who Have Sex with Men in Kenya.
(2014)
A qualitative assessment of Kenyan men who have sex with men taking daily and intermittent oral HIV pre-exposure prophylaxis (PrEP) found stigma, sex work, mobility, and alcohol impacted adherence. We analyzed quantitative ...
Pregnancy and HIV Disease progression in an early infection cohort from five African countries.
(Unuversity of Nairobi, 2017)
BACKGROUND:
Understanding associations between pregnancy and HIV disease progression is critical to provide appropriate counseling and care to HIV-positive women.
METHODS:
From 2006 to 2011, women less than age 40 ...
Clinical safety and immunogenicity of two hiv vaccines sev-g (np) and ad35-grin in HIV-uninfected, healthy adult volunteers
(University of Nairobi, 2014)
Development of vaccines that stimulate sustained humoral and/or cellular
immunity at mucosal HIV entry points is critical in the quest for an HIV vaccine. To achieve
this goal, we are investigating replication-competent ...
Assessment of anti-hiv-1 antibodies in oral and nasal compartments of volunteers from 3 different populations.
(University of Nairobi, 2016)
In this study, we assessed the feasibility of collecting standardized nasal and salivary samples at centers in Nairobi (Kenya), Kigali (Rwanda), and London (United Kingdom) using different collection devices and media ...
Broad HIV-1 inhibition in vitro by vaccine-elicited cd8(+) t cells in African adults.
(University of Nairobi, 2016)
We are developing a pan-clade HIV-1 T-cell vaccine HIVconsv, which could complement Env vaccines for prophylaxis and be a key to HIV cure. Our strategy focuses vaccine-elicited effector T-cells on functionally and structurally ...
Broadly Neutralizing Antibody Responses in a Large Longitudinal Sub-Saharan HIV Primary Infection Cohort.
(2016)
Broadly neutralizing antibodies (bnAbs) are thought to be a critical component of a protective HIV vaccine. However, designing vaccines immunogens able to elicit bnAbs has proven unsuccessful to date. Understanding the ...
National burden of hospitalized and non-hospitalized influenza-associated severe acute respiratory illness in Kenya, 2012-2014.
(University of Nairobi, 2017)
BACKGROUND:
Influenza-associated respiratory illness was substantial during the emergence of the 2009 influenza pandemic. Estimates of influenza burden in the post-pandemic period are unavailable to guide Kenyan vaccine ...
Bombali Virus in Mops condylurus Bat, Kenya
(2019-05)
Bombali virus (genus Ebolavirus) was identified in organs and excreta of an Angolan free-tailed bat (Mops condylurus) in Kenya. Complete genome analysis revealed 98% nucleotide sequence similarity to the prototype virus ...