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Now showing items 21-30 of 30
Antibody-dependent Cell-mediated Virus Inhibition Antibody Activity Does Not Correlate With Risk Of HIV-1 Superinfection
(University of Nairobi, 2013-05)
Previous studies of HIV-infected women with high risk behavior have indicated that neither neutralizing antibody nor cellular immunity elicited by an initial HIV-1 infection is associated with protection against superinfection ...
An Integrated approach for antiretroviral adherence and secondary HIVtransmission risk-reductionsupport by nurses in Kenya
(2012)
Ongoing antiretroviral therapy (ART) adherence
and secondary HIV transmission-risk reduction
(positive prevention) support are needed in resourcelimited
settings.We evaluated a nurse-delivered counseling
intervention ...
Incidence and correlates of Chlamydia trachomatis infection in a high-risk cohort of Kenyan women
(2013)
In Africa, data on Chlamydia trachomatis infection are scarce because reliable diagnosis is costly and not widely available. Our objective was to evaluate the incidence and correlates of C. trachomatis infection among ...
Molecular Definition Of Vaginal Microbiota In East African Commercial Sex Workers
(University of Nairobi, 2011-06)
Resistance to HIV infection in a cohort of commercial sex workers living in Nairobi, Kenya, is linked to mucosal and antiinflammatory factors that may be influenced by the vaginal microbiota. Since bacterial vaginosis (BV), ...
Genital ulceration does not increase HIV-1 shedding in cervical or vaginal secretions of women taking antiretroviral therapy.
(University of Nairobi, 2011)
OBJECTIVES:
Genital ulcer disease (GUD) is associated with increased HIV-1-RNA shedding in antiretroviral therapy (ART)-naive women. The effect of GUD on HIV-1 shedding among ART-treated women is not known. The objective ...
Effect of acquisition and treatment of cervical infections on HIV-1 shedding in women on antiretroviral therapy
(2010)
BACKGROUND:
Cervicitis increases the quantity of HIV-1 RNA in cervical secretions when women are not taking antiretroviral therapy (ART), and successful treatment of cervicitis reduces HIV-1 shedding in this ...
HIV-1 Clade D Is Associated with Increased Rates of CD4 Decline in a Kenyan Cohort
(2012)
HIV-1 is grouped phylogenetically into clades, which may impact rates of HIV-1 disease progression. Clade D infection in
particular has been shown to be more pathogenic. Here we confirm in a Nairobi-based prospective ...
HIV-1 Superinfection in Women Broadens and Strengthens the Neutralizing Antibody Response
(3/29/2012)
Identifying naturally-occurring neutralizing antibodies (NAb) that are cross-reactive against all global subtypes of HIV-1 is an
important step toward the development of a vaccine. Establishing the host and viral determinants ...
HIV viral set point and host immune control in individuals with HIV-specific CD8R T-cell responses prior to HIV acquisition
(2010)
OBJECTIVE:
Vaccine-induced CD8(+) T-cell responses in primates have been associated with a reduced simian immunodeficiency virus plasma viral load and enhanced T-cell responses, but cellular vaccines have shown limited ...
A prospective study of risk factors for herpes simplex virus type 2 acquisition among high-risk HIV-1 seronegative women in Kenya
(2011)
OBJECTIVES:
Several studies have demonstrated an association between herpes simplex virus type 2 (HSV-2) and HIV-1, but available data on risk factors for HSV-2 acquisition are limited. The objective of this analysis ...