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Primary human immunodeficiency virus type 1 infection: clinical manifestations among women in Mombasa, Kenya
(2000)
The occurrence of clinical manifestations associated with primary human immunodeficiency virus type 1 (HIV-1) infection was evaluated in a prospective cohort study of female sex workers in Mombasa, Kenya. Among 103 women ...
Effect of breastfeeding on mortality among HIV-1 infected women: a randomised trial.
(2001)
We have completed a randomised clinical trial of breastfeeding and formula feeding to identify the frequency of breastmilk transmission of HIV-1 to infants. However, we also analysed data from this trial to examine the ...
Resistance to HIV-1 infection among African sex workers is associated with global hyporesponsiveness in interleukin 4 production.
(2001)
We previously identified HIV-1 resistant prostitutes who remain persistently HIV-1 PCR- and
antibody-negative despite continued heavy exposure to HIV-1 through sex work. We hypothesized
that differences in virus-specific ...
Partner Notification Of Pregnant Women Infected With Syphilis In Nairobi, Kenya
(University of Nairobi, 2000-04-11)
We examined partner notification among syphilitic pregnant women in Nairobi. At delivery, 377 women were found to be rapid plasma reagin (RPR) reactive. Data were available for 94% of the partners of women who were tested ...
Health Seeking And Sexual Behaviour Among Primary Health Care Patients In Nairobi, Kenya
(University of Nairobi, 2002)
{ Observational studies have associated vitamin A deficiency with vaginal shedding of human immunodeficiency virus (HIV) type 1-infected cells and mother-to-child HIV-1 transmission. To assess the effect of vitamin A ...
HIV-1 neutralizing activity is correlated with increased levels of chemokines in saliva of HIV-1-exposed uninfected individuals.
(University of Nairobi,, 2008)
AIM:
Mucosal HIV-1 exposure stimulates a variety of mucosal immune responses, including IgA1-mediated virus neutralization, even in the absence of an established infection. We hypothesized that other immune molecules might ...
Safety and immunogenicity of recombinant low-dosage HIV-1 A vaccine candidates vectored by plasmid pTHr DNA or modified vaccinia virus Ankara (MVA) in humans in East Africa
(2008)
Summary: The safety and immunogenicity of plasmid pTHr DNA, modified vaccinia virus Ankara
(MVA) human immunodeficiency virus type 1 (HIV-1) vaccine candidates were evaluated in four
Phase I clinical trials in Kenya and ...
Gonococcal Cervicitis Is Associated With Reduced Systemic Cd8+ T Cell Responses In Human Immunodeficiency Virus Type 1-infected And Exposed, Uninfected Sex Workers.
(University of Nairobi, 2002)
Neisseria gonorrhoeae cervicitis and human immunodeficiency virus (HIV) type 1 frequently coinfect core transmitter populations, such as female sex workers. Gonococcal cervicitis is associated with increased viral shedding ...
Quantitative ex vivo analysis of functional virus-specific CD8 T lymphocytes in the blood and genital tract of HIV-infected women
(2003-05)
BACKGROUND:
CD8 T lymphocytes are important in HIV-1 control and mediate virus-specific immunity in the blood and genital tract. The induction and monitoring of mucosal CD8 cell responses will be an important component ...
Mucosal and plasma IgA from HIV-exposed seronegative individuals neutralize a primary HIV-1 isolate.
(University of Nairobi, 2000)
Abstract
OBJECTIVE:
To characterize functional properties of HIV-specific IgA in samples representing both systemic and mucosal compartments of HIV-1 highly exposed persistently seronegative (HEPS) individuals.
METH ...